JPRN-UMIN000005601已完成未知
Effect of the Combination of varsartan with HCTZ on circadian BP rhythm - Varsartan & HCTZ
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences0 个研究点目标入组 30 人开始时间: 2011年5月23日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
Of the 25 eligible patients, one had excess BP reduction during add-on HCTZ therapy and another was judged as excessive urine collection, and they were excluded from the study. Lower Na balance was produced by add-on HCTZ to ARB treatment without an increase of intrarenal renin-angiotensin system activity, leading to restoration of nocturnal hypertension. J Renin Angiotensin Aldosterone Syst. 2016 Jun 9;17(2):1470320316652032
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. previous treatment with ARB, other than valsartan, or diuretics 2 months before enrollment 2. contraindication to valsartan or HCTZ (history of allergic reaction to them, bilateral renal artery stenosis) 3. presence or possibility of pregnancy 4. HbA1c 9.0 or more % 5. GOT >100, or GPT >85 6. endocrine hypertension 7. accelerated o r malignant hypertension (progressive renal dysfunction with diastolic BP of >120-130 mmHg 8. serious conditions with congestive heart failure, coronary diseases, arrhythmia or systemic diseases 9. nephrotic syndrome (serum albumin <2.5 g/dl) 10. patients under hemodialysis therapy 11. any reason for ineligibility suggested by the attending doctor
研究者
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