Causal Role of Frontopolar Cortex for Motivation in Healthy Older Adults: a Transcranial Direct Current Stimulation Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- participants' decisions to exert cognitive or physical effort for monetary rewards
研究概览
简要总结
Motivation represents a core aspect of goal-directed behavior as it determines how much effort individuals are willing to invest to reach their goals. While research on effort-based decision-making focuses mainly on effort preferences in younger adults, loss of motivation might be a key component of the apathetic tendencies frequently seen in older adults. However, an open question refers to which brain mechanisms underlie motivational processes in older adults. The investigators have recently shown that the frontopolar cortex plays a crucial in motivating the exertion of rewarded effort in younger adults. The goal of the current study is to determine whether frontopolar cortex plays a crucial role for motivation also in older adults and may thus be a promising target for improving the motivation deficits in healthy aging. Participants perform computer-based experimental tasks measuring the propensity to exert cognitive or physical effort for monetary rewards. During task performance, participants receive anodal or sham transcranial direct current stimulation (tDCS) over their frontopolar cortex. The study tests whether tDCS over frontopolar cortex allows modulating participants' motivation to engage in rewarded effort.
详细描述
Motivation represents a core aspect of goal-directed behavior as it determines how much effort individuals are willing to invest to reach their goals. While research on effort-based decision-making focuses mainly on effort preferences in younger adults, loss of motivation might be a key component of the apathetic tendencies frequently seen in older adults. However, an open question refers to which brain mechanisms underlie motivational processes in older adults. The investigators have recently shown that the frontopolar cortex plays a crucial in motivating the exertion of rewarded effort in younger adults (Soutschek et al., 2018, Biological Psychiatry). The goal of the current study is to determine whether frontopolar cortex plays a crucial role for motivation also in older adults and may thus be a promising target for improving the motivation deficits in healthy aging. 30 older participants (65-80 years) perform computer-based experimental tasks measuring the propensity to exert cognitive or physical effort for monetary rewards. During task performance, participants receive 1 mA anodal or sham transcranial direct current stimulation (tDCS) over their frontopolar cortex. The study tests whether tDCS over frontopolar cortex allows modulating participants' motivation to engage in rewarded effort.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
The participants are blind to whether the participants receive anodal or sham stimulation in a session.
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 65-80 years
- •Informed consent as documented by signature
- •Normal or corrected-to-normal vision
- •Cognitive and language ability to understand study content and procedure
- •Normal cognitive functioning (assessed by MMST)
- •BDI-II score < 20
排除标准
- •Negative response to TMS/tDCS in past
- •History of seizure
- •History of stroke or heart attack
- •History of head injury
- •Psychiatric or neurological disorder
- •Metal in body/head
- •Implanted medical products like pacemaker, medical pumps, heart catheter
- •Currently taking medication affecting the central nervous system
- •Insufficient sleep in preceding night
- •Excessive consumption of alcohol within last 24 hours
研究组 & 干预措施
anodal transcranial direct current stimulation
anodal transcranial direct current stimulation (current strength: 1 mA, duration: 20 min) over the frontopolar cortex
干预措施: transcranial direct current stimulation (Device)
sham transcranial direct current stimulation
sham transcranial direct current stimulation (current strength: 1 mA, duration: 0.5 min) over the frontopolar cortex
干预措施: transcranial direct current stimulation (Device)
结局指标
主要结局
participants' decisions to exert cognitive or physical effort for monetary rewards
时间窗: All participants perform this decision-making task in both experimental sessions (i.e., both the anodal and the sham stimulation session) for 20 min while receiving anodal or sham stimulation.
The project seeks to test the causal role of FPC in discounting of cognitive and physical effort in healthy older adults. For that purpose, participants perform a task on a computer which requires the participants to decide whether the participants are willing to exert cognitive or physical effort for a monetary reward. Participants perform this task both under anodal and under sham stimulation. It is tested whether anodal, relative to sham, stimulation increases participants' willingness to engage in rewarded cognitive or physical effort.
次要结局
未报告次要终点