Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation

• Conditions: Rejection; Lung Transplantation

• Registration Number: NCT00558597
• Lead Sponsor: Hannover Medical School

Brief Summary

In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.

Detailed Description

Goal of the study is the establishment of biomarkers for early diagnosis of acute rejection, followed by a late validation of the paradigm with prospectively collected samples, which will be examined blinded.

Study Timeline

• Study First Submitted: 2007-11-14
• Study First Submitted QC: 2007-11-14
• Study First Posted: 2007-11-15
• Study Start: 2008-03
• Status Verified: 2008-09
• Last Update Submitted: 2011-07-19
• Last Update Posted: 2011-07-21
• Study Completion: 2011-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with stable graft function
• Patients with acute rejection

Exclusion Criteria

• Acute infection
• BOS

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Hannover Medical School; 🇩🇪 Hannover, Germany