Childhood Obesity Risk Markers
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- transcriptomic markers in children under 4 years of age that predict a predisposition to being overweight at age 6 (BMI > IOTF25).
研究概览
简要总结
Metabolic diseases, including childhood obesity, represent a major public health challenge. Studies in mice have identified transcriptomic markers in adipose tissue capable of predicting a predisposition to obesity prior to any weight gain. The MARIOBE project aims to translate this approach to young children (≤ 4 years old) in order to identify individual vulnerability to obesity at an early stage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 1 Day 至 4 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Child scheduled for surgery allowing for the harvesting of adipose tissue.
排除标准
- •Child whose holders of parental authority are protected by law
研究组 & 干预措施
early transcriptomic markers
干预措施: early transcriptomic markers (Other)
结局指标
主要结局
transcriptomic markers in children under 4 years of age that predict a predisposition to being overweight at age 6 (BMI > IOTF25).
时间窗: perioperative
Ranking of the discriminative capacity of adipocyte and blood transcripts before 4 years of age to predict the development of overweight (BMI \> IOTF25) at age 6, using Partial Least Squares Discriminant Analysis (PLS-DA).
次要结局
- analyze weight trajectories(at age 6 years)
- molecular and epigenetic mechanisms associated with the identified transcriptomic signatures.(at the time of blood ans adipose tissu sampling)
- comparison of transcriptomic expression levels between blood and adipose tissue(perioperative)
- develop a quantitative test based on digital PCR to define individual expression thresholds predictive of risk(at age 6 years)