Effects of probiotic in generalized anxiety disorder

Phase 3

Conditions: Generalized anxiety disorde.
Anxiety that is generalized and persistent but not restricted to, or even strongly predominating in, any particular environmental circumstances (i.e. it is free-floating). The dominant symptoms are variable but include complaints of persistent nervousne

Registration Number: IRCT20090901002394N39

Lead Sponsor: Iran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 48

Inclusion Criteria

DSM-V diagnosed of GAD
Adults between 18 and 65 years old
Willing to participate.

Exclusion Criteria

Having illness including liver disease and kidney disease, diabetes, immune deficiency, etc
Having psychological illnesses including psychosis, Suicidal ideation, bipolar disorder and major depression
People who are expected to have limited partnerships such as forgetfulness and pregnancy
Taking any medication in the previous 1 month
Taking any medication related to psychiatric diseases including antidepressants, antipsychotics, etc. (maximum of two times per week) and antibiotics in the previous 1 month
Taking any supplement including probiotic supplement, fiber, prebiotics, omega-3, vitamins and minerals in the previous 1 month; Consumption of fermented foods (except yogurt), such as sour cream, acidophilus milk, kefir and some cheeses such as blue vein cheese or Swiss cheese in the previous 1 month
substance abuse
The compliance less than 80%.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
BDNF. Timepoint: At baseline, after 2 month. Method of measurement: Blood test.;Hs-crp. Timepoint: At baseline, after 2 month. Method of measurement: Blood test.;Neuropeptide y. Timepoint: At baseline, after 2 month. Method of measurement: Blood test.

Secondary Outcome Measures