Can the sensitization profile towards hazelnut, peanut and birch pollen be used to predict the severity of clinical symptoms of hazelnut allergy in both children and adults?
Completed
- Conditions
- food allergyhazelnut allergy10001708
- Registration Number
- NL-OMON35609
- Lead Sponsor
- niversitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 176
Inclusion Criteria
children and adults with a hazelnut sensitization
Exclusion Criteria
congenital/aqcuired immunodeficiency
lymphoproliferative disease
systemic immunosuppression
insufficient knowledge of Dutch language
children from 3-6 years will be excluded from genetic research
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Based on literature and preliminary data, four determinants are identified,<br /><br>which we think are (most) predictive for the severity of the symptoms of<br /><br>hazelnut allergy. The determinants are: Cor a 1, Cor a 8, Cor a 9 and oleosin.<br /><br>First, the predictive value of each determinant will be assessed using<br /><br>univariate analysis. Second, a multivariable logistic regression model will be<br /><br>build starting with the strongest predictor (based on the relative risk<br /><br>obtained from univariate analysis).<br /><br>To make the prediction model applicable for clinical practice, a prediction<br /><br>rule will be made and for the different possible scores on the prediction rule<br /><br>(or categories of the score), we will present the probability of having severe<br /><br>symptoms of hazelnut allergy.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The analysis of IgE and T cell cross-reactivity concerns a secondary analysis<br /><br>to define potential mechanisms responsible for the difference in clinical<br /><br>severity of symptoms. We determine whether there are genetic associations by<br /><br>analysing these polymorfisms.</p><br>