A prospective, randomized clinical trial in split mouth design analyzing the influence of an autologous fibrin matrix (PRF) on wound healing and bone regeneration after osteotomy of displaced and retained third molars

Not Applicable

Recruiting

• Conditions: Regeneration of extraction sockets; K08.1; Loss of teeth due to accident, extraction or local periodontal disease

• Registration Number: DRKS00019229
• Lead Sponsor: niversitätsklinikum der Goethe-Universität Frankfurt am Main Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients in need of osteotomy of at least two third molars (at least 1 tooth on each side); Patients with informed consent (under age patients with parents approval); Patients at an age of at least 16 years

Exclusion Criteria

Patients younger than 16 years;
Patients with contraindication for surgery;
Patients allergic to necessary medication and/or medical devices;
Patients with chronic medication possibly influencing pain perception and/or inflammation and/or wound healing ;
Immunocompromised persons;
Patients without informed consent;
Pregnant or breast feeding women

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Pain (VAS)<br>- Swelling according to Gabka+Matsumara, measured between 5 reference points

Secondary Outcome Measures

Name	Time	Method
- wound healing and morbidity<br>- trismus (maximal mouth opening)<br>- post-surgery complications<br>- photo documentation of wound healing