Neuropsychological Assessment of Remediation for Cognitive Impairments in Schizophrenia
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Schizophrenic Disorders
- Sponsor
- Centre hospitalier de Ville-Evrard, France
- Enrollment
- 70
- Locations
- 2
- Primary Endpoint
- STROOP
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study evaluates the effect of a cognitive remediation program on neurocognitive, social cognitive and metacognitive functions designed for patients living with a schizophrenia spectrum disorder.
Detailed Description
Evaluation of the specific therapeutic efficacy of the ecological cognitive remediation program for schizophrenia spectrum disorder \[ECo-Sz\] on neurocognitive deficits, social cognition deficits and metacognition deficits of patients with a schizophrenia spectrum disorder. In this double-blind (patients, outcomes assessors) controlled randomized trial the investigators compare patients receiving Ecological Cognitive training program for schizophrenia spectrum disorder \[ECo-Sz\] to patients benefiting from recovery-oriented therapy \[ThOR\]. Patients are treated for two months and monitored for four months.
Investigators
Clémence ISAAC
Principal Investigator
Centre hospitalier de Ville-Evrard, France
Eligibility Criteria
Inclusion Criteria
- •Schizophrenia Disorder diagnosis, according to Diagnostic and Statistical Manual of mental disorders - Fifth edition (DSM-V) - Patient stabilized in terms of positive and negative symptomatology (absence or presence of weak positive and negative symptoms)
- •Positive and Negative stable symptoms (no or few positive and negative symptoms)
- •Stable and effective minimum dose of medication (antipsychotic) for the last three months
- •Cognitive complaint expressed by the patient
- •Informed consent form read, initialed and signed
- •Understanding of spoken and read French
- •Patient registered on the social welfare system
Exclusion Criteria
- •Other diagnosis at the forefront than Schizophrenia of the DSM-V
- •Medical history neurological disorder resulting in hospitalization
- •Acute episode in the last three month
- •Somatic disorders resulting in cognitive impairment
- •Engagement in a research protocol either currently or over the last month
- •Neuropsychological assessment evaluation during the last six month
- •Patients under the protection of a conservator (simple or reinforced)
- •Individuals in vulnerable circumstances
Outcomes
Primary Outcomes
STROOP
Time Frame: pre-inclusion
Interference score
TMTB
Time Frame: pre-inclusion
Trail Making Test
Litteral score of Verbal fluences
Time Frame: pre-inclusion
Litteral score of Verbal fluences
GO/NOGO
Time Frame: pre-inclusion
cognitive control score
tower of Hanoi
Time Frame: pre-inclusion
Tower planning total score from tower of Hanoi
Matrix test (WAIS-IV)
Time Frame: pre-inclusion
The perceptual reasoning score of the Matrix test.
Secondary Outcomes
- PANSS(pre-inclusion)
- ERF(Twenty six week)
- ERF-CS(Twenty six week)
- QFS(Twenty six week)
- Mini-500(pre-inclusion)
- CTQ(pre-inclusion)
- EESEP(Twenty six week)
- MCQ-30(Twenty six week)
- SAIQ(Twenty six week)
- SCS(Twenty six week)
- SDS(Twenty six week)
- STORI(Twenty six week)