Can thrombin generation assay infer plasma FVIII:C in adult Thai hemophilia A?
Completed
- Conditions
- The adult severe hemophilia A patients followed up at Hematology clinic, Siriraj hospital.Hemophilia A, Hemophilia, Thrombin generation assay, FVIII, Inhibitors, Bypassing agents
- Registration Number
- TCTR20211027003
- Lead Sponsor
- Siriraj Hospital , Mahidol University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
1. Severe hemophilia A
2. Age of more than 18 years
3. Last FVIII transfusion of longer than 72 hours
Exclusion Criteria
1. concomitant antiplatelets and/or anticoagulants used
2. chronic kidney disease stage 4-5 (glomerular filtration rate of less than 30 mL/minute)
3. liver impairment (prothrombin time of longer than 16 seconds)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Thrombin generation assay parameters at the day of blood collection calibrated automated thrombography (CAT)
- Secondary Outcome Measures
Name Time Method correlation of TGA parameters and FVIII:C at the day of blood collection calibrated automated thrombography (CAT)