Resistance Training in Patients With Morbid Obesity
- Conditions
- Morbid ObesityObesityRisk Factor, CardiovascularPhysical ActivityMetabolic Syndrome
- Registration Number
- NCT03921853
- Lead Sponsor
- Universidad de Los Lagos
- Brief Summary
The researchers will conduct a study for avoiding the metabolic syndrome in morbid obese patients. Thus, the aim of the present will be determine the effects of a resistance training programme (RT) in preventing or attenuating metabolic syndrome (MetS) in patients with morbid obesity. A second aim will be report the prevalence of non-responders in terms of improvements in MetS markers and other co-variables considered.
- Detailed Description
The prevalence of metabolic syndrome (MetS) and cardiovascular disease is expected to rise along with the global obesity epidemic. MetS is a cluster of clinical risk factors, including abdominal (visceral) obesity, hypertension, elevated serum triglycerides, low serum high-density lipoprotein (HDL) and hyperglycaemia.The MetS for example, significantly decreases the life expectancy of individuals with morbid obesity and increases the disease burden and economic costs associated with healthcare. In this sense, more recently, there was reported that body mass index (BMI) and fat distribution showed higher associations with inflammation, fat indices, and more prevalence of MetS in morbidly obese subjects, claiming for an early prevention of the MetS in the morbid obese state.
Exercise training has proven to be effective in inducing a clinically significant weight loss and reducing cardiovascular risk. Exercise have reported to be associated with increased muscle mass, decreased body fat, and improved metabolic profile (i.e., improved glucose control and lipid levels). In addition, supervised RT improved muscle strength and functional capacity in patients with obesity undergoing bariatric surgery. However, although RT has been widely studied in obesity, there is little information in the morbid obesity. On the other hand, there is poor knowledge similarly, about the interindividual variability to exercise training in terms of responders and non-responders (NR). Thus, considering the poor knowledge about the MetS prevention in morbid obese patients, as well as the little information about Responders and Non-Responders for improving MetS outcomes, the aim of this study will be determine the effects of a RT program on cardio-metabolic outcomes of MetS in patients with morbid obesity. A second aim will be report the prevalence of non-responders in terms of the effects of resistance training on MetS markers and other health-related variables.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 39
Inclusion Criteria:
- Older than 18 and younger and ≤65 years of age.
- With risk factors to Metabolic syndrome
- With obesity and morbid obesity condition
- Medical authorization by a physician.
- Physical limitations (e.g., restricting injuries of the musculoskeletal system, or dependent of a third person).
- Exercise-related dyspnoea or respiratory alterations.
- Chronic heart disease with any worsening in the last month.
- Adherence rate of less than 80% of the total interventions.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Fasting glucose Change from Baseline Fasting glucose at 20-weeks of Resistant Training Component of the Metabolic Syndrome
High density lipoprotein Change from Baseline High density lipoprotein at 20-weeks of Resistant Training Component of the Metabolic Syndrome
Systolic blood pressure and diastolic blood pressure from Baseline Systolic blood pressure and diastolic blood after 20-weeks of Resistant Training Component of the Metabolic Syndrome
Waist circumference Change from Baseline Waist circumference at 20-weeks of Resistant Training Component of the Metabolic Syndrome
Triglycerides Change from Baseline Triglycerides at 20-weeks of Resistant Training Component of the Metabolic Syndrome
- Secondary Outcome Measures
Name Time Method Body mass index Change from Baseline Body mass index at 20-weeks of Resistant Training Anthropometric
Body mass Change from Baseline Body mass at 20-weeks of Resistant Training Anthropometric
Total cholesterol Change from Baseline Total cholesterol at 20-weeks of Resistant Training Measured by plasma sample
Low density lipoprotein Change from Baseline Low density lipoprotein at 20-weeks of Resistant Training Measured by plasma sample
Six minutes walking test Change from Baseline Six minutes walking test density lipoprotein at 20-weeks of Resistant Training Endurance performance
One maximum repetition of biceps curl Change from Baseline One maximum repetition of biceps curl at 20-weeks of Resistant Training Strength Performance
Handgrip muscle strength Change from Baseline Handgrip muscle strength at 20-weeks of Resistant Training Muscle strength
Trial Locations
- Locations (1)
Cristian ALvarez
🇨🇱Osorno, Llanquihue, Chile
Cristian ALvarez🇨🇱Osorno, Llanquihue, Chile