The effects of a GABA supplement versus a placebo on glucose tolerance and blood pressure in prediabetics
- Conditions
- HypertensieType 2 diabetes10018424elevated blood pressure
- Registration Number
- NL-OMON49999
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 52
- Age between 50 and 70
- BMI higher or equal to 25 kg/m2
- Impaired fasting glucose (fasting glucose * 5.6 and * 6.9 mmol/L) or/and
- Impaired glucose tolerance (glucose levels * 7.8 and * 11.1 mmol/L, 2-hours
after an OGTT or/and glucose levels *8.6 mmol/L, 1-hour after an OGTT)
- Has been diagnosed with diabetes
- Having other conditions, like liver, pancreatic, cardiovascular,
gastro-intestinal or endocrine diseases, that could influence the study results
- Use of medications or supplements that could influence the study results
- Sensitive to medical skin adhesives
- More than 5kg weight change in the past 12 weeks
- Excessive alcohol consumption (>21 glasses/week for men and >14 glasses/week
for women on average)
- Being an employee of Wageningen University, division Human Nutrition and
Health
- Currently a research subject in other research
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter of this study is the postprandial glycaemic response<br /><br>during a 2 hour oral glucose tolerance test (OGTT) before and after the<br /><br>intervention period.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Postprandial insulin and glucagon response, plasma free fatty acids, HbA1c,<br /><br>glucose variability with flash glucose monitoring, blood pressure, markers of<br /><br>inflammation, TG and LDL and HDL cholesterol, sleep habits, depression,<br /><br>anxiety, GABA and glutamate plasma levels and the acute effects of GABA on<br /><br>postprandial glucose response and blood pressure.</p><br>