Comparison of the effects of Pregabalin, Dexmedetomidine, and their combination on the haemodynamic response and anaesthetic requirements
Phase 4
Completed
- Conditions
- Health Condition 1: null- ASA Grade 1 and 2
- Registration Number
- CTRI/2017/09/009862
- Lead Sponsor
- VMMC and Safdarjung Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
Patients scheduled to undergo elective laparoscopic cholecystectomy.
ASA grades 1 and 2.
Adult patients 18-65 years of age of either sex.
Exclusion Criteria
1) patients with hypertension,morbid obesity, and cardiac, renal, hepatic, endocrine or pulmonary dysfunction
2) ASA grades 3 and 4
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pulse,blood pressure,oxygen saturation,end tidal carbon dioxide, isoflurane concentration,fentanyl requirement, propofol requirement, ramsay sedation score, Visual Analogue ScaleTimepoint: baseline, 10, 20,30,40,45,50,55,60 minutes after premedication <br/ ><br>before induction, after 1,2,3 minutes of induction, after 1,3,5,10,15,30,45,60,75 minutes of intubation, before, after and end of pneumoperitoneum <br/ ><br>15 minutes, 1 hour, 2 hours after extubation
- Secondary Outcome Measures
Name Time Method time taken for patient to respond after reversal, time taken for extubation after reversalTimepoint: 15 minutes, 60 minutes, and 120 minutes postoperatively