Investigation of the Clinical Pregnancies Obtained After Cryopreservation of Donor Oocytes With an Open or Closed Device
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Clinical pregnancy
研究概览
简要总结
This randomized pilot study will assess if there is a difference in clinical pregnancies using donor oocytes cryopreserved in either a closed or a semi-closed vitrification device.
详细描述
Oocyte cryopreservation was optimized by the use of a new technique: vitrification. Vitrification can be performed using either open devices (where the oocytes are in direct contact with the liquid nitrogen) or closed systems (where the oocytes are never in contact with liquid nitrogen). Previous studies have associated the use of open devices to higher oocyte survival rates and better embryo development. However, any beneficial effect on clinical pregnancy rates is yet to be proven. Hence, the objective of this study is to compare the clinical pregnancy rates of open and closed oocyte vitrification devices.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 47 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •this is a pragmatic randomized clinical trial. Hence, all consenting oocyte recipients will be eligible for the study
排除标准
- •women who do not consent or that cannot comprehend the investigational nature of the study
结局指标
主要结局
Clinical pregnancy
时间窗: 7 weeks
Pregnancy determined by ultrasound
次要结局
- survival(1 week)
- fertilization(1 week)
- embryo development(2 weeks)
研究者
Neelke De Munck
Master in Science
Universitair Ziekenhuis Brussel