Comparison of Reproductive Outcomes After Progestin-primed Ovarian Stimulation With Dydrogesterone Versus Cetrorelix to Inhibit Spontaneous Ovulation in Oocyte Donation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 202
- 主要终点
- Clinical pregnancy per transfer
研究概览
简要总结
Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm. The OD cycles were triggered with triptoreline acetate and the trigger criterion was ≥3 follicles of diameter >18mm.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 30 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Oocyte donors between 21 and 30 years old, with regular menstrual cycles (24-35 d) and a body mass index (BMI) between 18 and 28 kg/m2 without any relevant personal or family history
排除标准
- •AMH less than 3 ng/dL
- •A positive screening for sexually transmitted diseases
研究组 & 干预措施
DYG
oocyte donors undergoing controlled ovarian stimulation in a progestin-primed ovarian stimulation protocol with DYG protocol (20mg/day)
干预措施: Dydrogesterone (Drug)
结局指标
主要结局
Clinical pregnancy per transfer
时间窗: 12 weeks after ET
Live Birth Rate per transfer
时间窗: 40 weeks after ET
Miscarriage rate
时间窗: 12 weeks after ET
次要结局
- Number of mature oocytes(1 day after IVF)
- Number of blastocists(5-6 days after OPU)
- Number of oocytes retrieved(at time of oocyte retrieval)
- Number of fertilized oocytes(1 day after IVF)
研究者
Jose Antonio Moreno
MD, PhD
Clinica de la Mujer Medicina Reproductiva, Chile