DYG Versus Cetrorelix in Oocyte Donation
- Registration Number
- NCT05577806
- Lead Sponsor
- Clinica de la Mujer Medicina Reproductiva, Chile
- Brief Summary
Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm. The OD cycles were triggered with triptoreline acetate and the trigger criterion was ≥3 follicles of diameter \>18mm.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 202
Inclusion Criteria
- Oocyte donors between 21 and 30 years old, with regular menstrual cycles (24-35 d) and a body mass index (BMI) between 18 and 28 kg/m2 without any relevant personal or family history
Exclusion Criteria
- AMH less than 3 ng/dL
- A positive screening for sexually transmitted diseases
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description DYG Dydrogesterone oocyte donors undergoing controlled ovarian stimulation in a progestin-primed ovarian stimulation protocol with DYG protocol (20mg/day)
- Primary Outcome Measures
Name Time Method Clinical pregnancy per transfer 12 weeks after ET Live Birth Rate per transfer 40 weeks after ET Miscarriage rate 12 weeks after ET
- Secondary Outcome Measures
Name Time Method Number of mature oocytes 1 day after IVF Number of blastocists 5-6 days after OPU Number of oocytes retrieved at time of oocyte retrieval Number of fertilized oocytes 1 day after IVF