Evaluation of the effect of Intravenous dexamethasone vs. ketamine gargle vs. intravenous dexamethasone combined with ketamine gargle on post operative sore throat and hoarseness

Not Applicable

Conditions: Condition 1: acute sore throat. Condition 2: hoarseness.
Acute pharyngitis, unspecified
Dysphonia

Registration Number: IRCT201305165362N5

Lead Sponsor: Anesthesiology and Critical Care Research Center,Isfahan University of Medical Sciences, Isfahan, Ir

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 140

Inclusion Criteria

Patients without a history of preoperative sore throat and asthma;Patients without recent NSAID medication; mouth opening of >3.5cm;a Cormack score of lower than 4; patients with duration of surgery between 60-300 min ;known allergies to study drugs; known difficulty with tracheal intubation.
Exclusion criteria were: Those who required more than one attempt for tracheal intubation; Patients with the requirement of mechanical lung ventilation after surgery in the intensive care unit.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sore throat. Timepoint: On arrival in the post-anesthesia care unit (0 h), and at 2, 4, 8,16and 24 h thereafter,. Method of measurement: 0, no sore throat; 1, mild sore throat (complains of sore throat only on asking); 2, moderate sore throat (complains of sore throat on his/her own); and 3, severe sore throat (change of voice or hoarseness, associated with throat pain).;Hoarseness. Timepoint: On arrival in the post-anesthesia care unit (0 h), and at 2, 4, 8,16and 24 h thereafter,. Method of measurement: watching-0, No hoarseness; 1, Hoarseness at the time of interview, but noted only by patient; 2, Hoarseness that is readily apparent, but mild; 3, Hoarseness that is readily apparent and severe.

Secondary Outcome Measures

Name	Time	Method
Recovery time(min). Timepoint: times from discontinuation of anesthesia until the time to achieve a modified Aldrete score of 9. Method of measurement: aldrete score.;The duration of tracheal intubation. Timepoint: the duration of tracheal intubation. Method of measurement: watching.;Sedation. Timepoint: during interviewed the patients to investigate the POST(post operative sore throat) (0,2,4,8,16,24h after tracheal extubation). Method of measurement: using the four-point Observer’s Assessment of Alertness/ Sedation (OAA/S) scale (where 0 = awake/alert and 3 = deep sleep).