Evaluation of the effect of Intravenous dexamethasone vs. ketamine gargle vs. intravenous dexamethasone combined with ketamine gargle on post operative sore throat and hoarseness
Not Applicable
- Conditions
- Condition 1: acute sore throat. Condition 2: hoarseness.Acute pharyngitis, unspecifiedDysphonia
- Registration Number
- IRCT201305165362N5
- Lead Sponsor
- Anesthesiology and Critical Care Research Center,Isfahan University of Medical Sciences, Isfahan, Ir
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 140
Inclusion Criteria
Patients without a history of preoperative sore throat and asthma;Patients without recent NSAID medication; mouth opening of >3.5cm;a Cormack score of lower than 4; patients with duration of surgery between 60-300 min ;known allergies to study drugs; known difficulty with tracheal intubation.
Exclusion criteria were: Those who required more than one attempt for tracheal intubation; Patients with the requirement of mechanical lung ventilation after surgery in the intensive care unit.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sore throat. Timepoint: On arrival in the post-anesthesia care unit (0 h), and at 2, 4, 8,16and 24 h thereafter,. Method of measurement: 0, no sore throat; 1, mild sore throat (complains of sore throat only on asking); 2, moderate sore throat (complains of sore throat on his/her own); and 3, severe sore throat (change of voice or hoarseness, associated with throat pain).;Hoarseness. Timepoint: On arrival in the post-anesthesia care unit (0 h), and at 2, 4, 8,16and 24 h thereafter,. Method of measurement: watching-0, No hoarseness; 1, Hoarseness at the time of interview, but noted only by patient; 2, Hoarseness that is readily apparent, but mild; 3, Hoarseness that is readily apparent and severe.
- Secondary Outcome Measures
Name Time Method Recovery time(min). Timepoint: times from discontinuation of anesthesia until the time to achieve a modified Aldrete score of 9. Method of measurement: aldrete score.;The duration of tracheal intubation. Timepoint: the duration of tracheal intubation. Method of measurement: watching.;Sedation. Timepoint: during interviewed the patients to investigate the POST(post operative sore throat) (0,2,4,8,16,24h after tracheal extubation). Method of measurement: using the four-point Observer’s Assessment of Alertness/ Sedation (OAA/S) scale (where 0 = awake/alert and 3 = deep sleep).