A study to analyse the effect of intravenous dexamethasone in pregnant females who are undergoing cesarean section under regional Anesthesia through spinal route
Not Applicable
- Conditions
- Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
- Registration Number
- CTRI/2022/04/041979
- Lead Sponsor
- Department of Anaesthesiology and Critical Care Pt B D Sharma PGIMS Rohtak
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Parturients between 20 to 35 years of age belonging to ASA (American Society of Anaesthesiologists) Grade II undergoing Lower Segment Cesarean section (LSCS) under spinal anaesthesia.
Exclusion Criteria
1. Patient refusal.
2. Pregnancy induced hypertension.
3. Preexisting hemodynamic instability, preexisting diabetes, cardiac ailment
4. Pre-existing neuropathy or nerve block that could compromise study assessments.
5. Preoperative use of systemic corticosteroids.
6. History of allergy or hypersensitivity to local anaesthetics, dexamethasone or other drugs
used in this study.
7. Any contraindication to spinal anaesthesia (coagulopathy, local infection at the site of
injection).
8.Conversion to general anaesthesia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To determine the effect of dexamethasone on the duration of sensory block after spinal <br/ ><br>anaesthesia <br/ ><br>2. To determine the effect of dexamethasone on the duration of motor block after spinal <br/ ><br>anaesthesia.Timepoint: Time between spinal anaesthesia and T6 or higher dermatome blockade. Maximum height of the sensory blockade attained at 20 minutes. Time of regression of sensory blockade to L1 dermatome. Time between spinal anaesthesia to Bromage score of III or higher. Maximum degree of motor blockade at 20 min. Time of regression of motor block from peak motor blockade to Bromage score of II.
- Secondary Outcome Measures
Name Time Method Duration of post-operative analgesia and complications if anyTimepoint: Time from the intrathecal injection to the time of <br/ ><br>the first complaint of pain. Blood pressure and heart rate will be recorded immediately after spinal anesthesia and then every 5 minutes till the regression of sensory block to L1 and motor block to Bromage score of II. Any episode of hypotension (fall in MAP more than 20% of baseline), bradycardia (heart rate 60 beats /min) will be recorded and managed as per standard protocol