comparing normal breathing for 3 minutes and 8 deep breaths in 1 minute to achieve better oxygenation before giving general anaesthesia

Completed

Conditions: preoxygenation / denitrogenation

Registration Number: CTRI/2017/05/008498

Lead Sponsor: P D Hinduja National Hospital and MRC

Brief Summary: This was a prospective, randomized, crossover study comparing two preoxygenation techniques: eight vital capacity (VC) breaths vs. three minutes tidal volume (TV) breaths in 270 patients undergoing elective surgery under general anaesthesia. It was a single centre study conducted at P. D. Hinduja National Hospital and Medical Research Centre, Mumbai. The primary outcome is to identify which of the two techniques of preoxygenation is effective across the study group. The secondary outcome is to identify the effectiveness of either technique of preoxygenation in overweight and obese patients. As it was a crossover study all patients underwent both techniques of preoxygenation. However, the patients were randomized to either perform the TV or VC maneuver first. This randomization into two groups was done by a computer generated sequence of random numbers. All the patients were given a 250head up position for both the techniques. Patients assigned to Group One were instructed to breathe at normal TV for 3 min through a close fitting mask. Over the next ten minutes the patients breathed room air to allow the PAO2to come back to baseline before crossing over to VC breathing. Patients assigned to Group Two were first instructed to take eight VC breaths, followed by ten minutes of room air breathing before they crossed over to the TV breathing. Preoxygenation was carried out with 15 L/min of FGF with FiO2 of 1.0 using the circle system. The ETO2 achieved was sampled at the patient end, on completion of each technique. After data collection, data entry was done in Excel. Data analysis was done using SPSS Software version 20.0.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 270

Inclusion Criteria

ASA physical status I and II patients posted for elective surgery under general anaesthesia.

Exclusion Criteria

1.pre existing respiratory or cardiac diseases 2.anticipated difficult airway 3.pregnancy 4.anticipated difficult mask ventilation 5.uncooperative patients 6.claustrophobia 7.patient refusal.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify which technique of preoxygenation : 3 minutes tidal volume breathing and eight vital capacity breaths, is effective across the study group.	3 minutes for tidal volume breathing and 8 vital capacity breaths

Secondary Outcome Measures

Name	Time	Method
To identify which technique of preoxygenation : 3 minutes tidal volume breathing and eight vital capacity breaths, is effective in overweight and obese patients.	3 minutes for tidal volume breathing and 8 vital capacity breaths

Trial Locations

Locations (1): P D Hinduja National Hospital and MRC
🇮🇳
(Suburban), MAHARASHTRA, India
P D Hinduja National Hospital and MRC
🇮🇳(Suburban), MAHARASHTRA, India
Dr Anjali Pingle
Principal investigator
9833733915
dranjalipingle@gmail.com