NCT05277233招募中不适用
Endothelial Dysfunction and Cardiovascular Risk After Preeclampsia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Myocardial perfusion
研究概览
简要总结
Investigation of cardiovascular risk 5-15 years after early or late-onset preeclampsia by adenosine stress Magnetic Resonance Imaging and non-invasive methods like retinal vessel analysis, skin measurement of advanced glycation end products, flow-mediated dilation or pulse wave analysis in comparison to women after healthy pregnancies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •18-60 years
- •5-15 years postpartum
排除标准
- •Atrioventricular block, chronic obstructive pulmonary disease, bronchial asthma
- •Pregnancy and/or active breastfeeding
- •Glaucoma disease, epilepsy
- •In addition for MRI: metal implants, electric devices, intolerance of contrast media, claustrophobia, renal or hepatic dysfunction (GFR < 30 ml/min)
结局指标
主要结局
Myocardial perfusion
时间窗: Day 2
Measured by adenosine stress Magnetic Resonance Imaging (ml/min/g)
次要结局
- Immune cell phenotypes(Day 1)
- Body fat mass(Day 1)
- Body fat-free mass(Day 1)
- Choroidal thickness(Day 1)
- Arterial dilation induced by retinal flicker stimulation(Day 1)
- Concentration of brain natriuretic peptide(Day 1)
- Urinary protein(Day 1)
- Reactive hyperemia index(Day 1)
- Systolic blood pressure(Day 1)
- Concentration of N-terminal prohormone of brain natriuretic peptide(Day 1)
- Advanced glycation end products(Day 1)
- Pulse wave velocity(Day 1)
- Cardiac fibrosis(Day 2)
- Hand grip strength(Day 1)
- Diastolic blood pressure(Day 1)
- Flow-mediated dilation(Day 1)
- Macular volume(Day 1)
- Venous dilation induced by retinal flicker stimulation(Day 1)
研究者
Kristin Kraeker
Principal Investigator
Charite University, Berlin, Germany
研究点 (1)
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