Change in Liver Enzymes After General or Spinal Anesthesia in Patients With Preoperatively Elevated Liver Enzymes

Not Applicable

Recruiting

• Conditions: Digestive System; Liver Enzymes

• Registration Number: PACTR201804002973186
• Lead Sponsor: Cairo University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-01-14
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Adult healthy ASA I, II patients, both genders, aged 18 ¿ 60 years, with
stationary elevated liver enzymes < 2 folds undergoing elective lower abdominal
wall or limb surgeries with expected operation time less than 2 hours

Exclusion Criteria

¿ ASA class III or IV
¿ Age >60 years or <18 years
¿ Patients undergoing intraperitoneal and laparoscopic procedures.
¿ Acute viral hepatitis: inflammation of the liver caused by infection with
one of the five hepatitis viruses. In most people, the inflammation begins
suddenly and lasts only a few weeks.
¿ Acute alcoholic hepatitis: is inflammation of the liver due to excessive
intake of alcohol. It is usually found in association with fatty liver, an early
stage of alcoholic liver disease, and may contribute to the progression of
fibrosis, leading to cirrhosis.
¿ Severe chronic hepatitis: is inflammation of the liver that lasts at least 6
months.
¿ Child¿s C class classification: this score is used to assess the prognosis of
chronic liver disease, mainly cirrhosis.
¿ Severe coagulopathy: a pathological condition that reduces the ability of
the blood to coagulate, resulting in uncontrolled bleeding. A platelet count
of < 50 x 109 /L will be considered at high risk of increased bleeding.
¿ Severe extrahepatic complication (Hypoxemia, Acute renal failure¿)
¿ Pregnant, diabetic patients
¿ Patients having an auto-immune disease
¿ Patients taking anticoagulant drugs or drugs that cause elevated liver
enzymes (non-steroidal anti-inflammatory drugs, antibiotics, antiepileptic drugs, inhibitors of hydroxyl-methyl-glutaryl¿coenzyme a reductase
(statins), and anti-tuberculosis drugs) were excluded from the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified