The effect of probiotics on changes in liver enzymes, lipid factors and ultrasound evidence in children and adolescents aged 10 to 18 years with non-alcoholic fatty liver
Phase 3
- Conditions
- on-alcoholic fatty liver disease.Non-alcoholic fatty liver diseaseDB92
- Registration Number
- IRCT20220314054279N1
- Lead Sponsor
- Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Children and adolescents 10 to 18 years of age with non-alcoholic fatty liver disease confirmed by ultrasound and ALT more than 1.5 to 5 times normal
Exclusion Criteria
Patients with alcoholic steatohepatitis
Patients with systemic diseases (such as diabetes), inflammatory diseases, autoimmune diseases of the liver
Positive serology of viral hepatitis
Positive AMA ANA
Positive Ceruloplasmin
Children with hypothyroidism
Taking nutritional supplements
Other secondary causes of fatty liver
Patients with any medication that affects the liver
Liver enzyme levels are more than 6 times normal
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method iver enzymes (ALT,AST). Timepoint: At the beginning of the study, 8 weeks after taking the drug. Method of measurement: blood test.;Lipid factors (cholesterol, LDL, HDL). Timepoint: At the beginning of the study, 8 weeks after taking the drug. Method of measurement: blood test.;Fatty liver grade. Timepoint: At the beginning of the study, 8 weeks after taking the drug. Method of measurement: Sonography.
- Secondary Outcome Measures
Name Time Method Body mass index. Timepoint: At the beginning of the study, 8 weeks after taking the drug. Method of measurement: Meters to measure height and scales to measure weight.;Fasting blood sugar. Timepoint: At the beginning of the study, 8 weeks after taking the drug. Method of measurement: Blood test.