Comparative Study of the Change in Liver Enzymes After General or Spinal Anesthetic Techniques in Patients With Preoperatively Elevated Liver Enzymes

Cairo University0 个研究点目标入组 60 人开始时间: 2018年1月14日最近更新: 2023年5月29日

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•Adult healthy ASA I, II patients, both genders, aged 18 ¿ 60 years, with
•stationary elevated liver enzymes < 2 folds undergoing elective lower abdominal
•wall or limb surgeries with expected operation time less than 2 hours

•¿ ASA class III or IV
•¿ Age >60 years or <18 years
•¿ Patients undergoing intraperitoneal and laparoscopic procedures.
•¿ Acute viral hepatitis: inflammation of the liver caused by infection with
•one of the five hepatitis viruses. In most people, the inflammation begins
•suddenly and lasts only a few weeks.
•¿ Acute alcoholic hepatitis: is inflammation of the liver due to excessive
•intake of alcohol. It is usually found in association with fatty liver, an early
•stage of alcoholic liver disease, and may contribute to the progression of
•fibrosis, leading to cirrhosis.
•¿ Severe chronic hepatitis: is inflammation of the liver that lasts at least 6
•¿ Child¿s C class classification: this score is used to assess the prognosis of
•chronic liver disease, mainly cirrhosis.
•¿ Severe coagulopathy: a pathological condition that reduces the ability of
•the blood to coagulate, resulting in uncontrolled bleeding. A platelet count
•of < 50 x 109 /L will be considered at high risk of increased bleeding.
•¿ Severe extrahepatic complication (Hypoxemia, Acute renal failure¿)
•¿ Pregnant, diabetic patients
•¿ Patients having an auto-immune disease
•¿ Patients taking anticoagulant drugs or drugs that cause elevated liver
•enzymes (non-steroidal anti-inflammatory drugs, antibiotics, antiepileptic drugs, inhibitors of hydroxyl-methyl-glutaryl¿coenzyme a reductase
•(statins), and anti-tuberculosis drugs) were excluded from the study

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