Acute MRI-techniques for the Detection of Ischemic Lesions After Transient Ischemic Attack
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 199
- 试验地点
- 1
- 主要终点
- frequency of patients with ischaemic lessions on DTI
研究概览
简要总结
The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).
Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.
It is possible that the addition of Arterial spin labeling (ASL) perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate diagnosis.
详细描述
The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).
Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.
It is possible that the addition of ASL-perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate and selective diagnosis of TIA.
Patients admitted with clinical signs of TIA can be included. Patients will be examined with the TIA protocol in reference to the standardized clinical care:
- 1,5 tesla gradient echo and 3 tesla Susceptibility weighted imaging (SWI) to detect microbleed as sign of small vessel disease.
- Axial T2 FLAIR to detect white matter lesions.
- Axial DWI to detect areas with impeded diffusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical signs of TIA
- •Informed consent
- •No serious respiratory or cardiac implications
排除标准
- •Contraindications to MRI
结局指标
主要结局
frequency of patients with ischaemic lessions on DTI
时间窗: on first MRI
We want to assess the frequency of patients in whom a diffusion restricted lesion can only be observed on DTI
次要结局
未报告次要终点
研究者
Hanne Christensen
Associate Research Professor, Consultant Neurologist
Bispebjerg Hospital