Acute MRI in Transient Ischemic Attack

Completed

• Conditions: Ischemic Attack, Transient

• Registration Number: NCT01531946
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).

Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.

It is possible that the addition of Arterial spin labeling (ASL) perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate diagnosis.

Detailed Description

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).

Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.

It is possible that the addition of ASL-perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate and selective diagnosis of TIA.

Patients admitted with clinical signs of TIA can be included. Patients will be examined with the TIA protocol in reference to the standardized clinical care:

1. 1,5 tesla gradient echo and 3 tesla Susceptibility weighted imaging (SWI) to detect microbleed as sign of small vessel disease.

2. Axial T2 FLAIR to detect white matter lesions.

3. Axial DWI to detect areas with impeded diffusion.

(Total scantime 10min)

If no signs of ischemic lesions is detected the following additional research scan-protocol will be initiated:

1. Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia.

2. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions.

(Total additional scantime 10min)

All in All 20min in the scanner.

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-02-09
• Study First Submitted QC: 2012-02-10
• Study First Posted: 2012-02-13
• Primary Completion: 2017-05
• Study Completion: 2017-05
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-26
• Last Update Posted: 2021-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 199

Inclusion Criteria

• Clinical signs of TIA
• Informed consent
• No serious respiratory or cardiac implications

Exclusion Criteria

• Contraindications to MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
frequency of patients with ischaemic lessions on DTI	on first MRI	We want to assess the frequency of patients in whom a diffusion restricted lesion can only be observed on DTI

Trial Locations

Locations (1)

Bispebjerg Hospital; 🇩🇰 Copenhagen, Capital Region, Denmark