Blood Pressure After Endovascular Stroke Therapy-II: A Randomized Trial
Overview
- Phase
- Phase 2
- Intervention
- Hydralazine
- Conditions
- Acute Stroke
- Sponsor
- University of Cincinnati
- Enrollment
- 120
- Locations
- 3
- Primary Endpoint
- Final Infarct Volume
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to assess the safety of lowering blood pressure in acute stroke patients that are successfully treated with a mechanical thrombectomy procedure. The investogators will evaluate the hypothesis that lower blood pressure management strategies do not result in larger volume of stroke or worse 3-month clinical outcome in these patients.
Detailed Description
Several thousand patients suffer from an ischemic stroke caused by an occlusion of a large blood vessel supplying the brain. Endovascular mechanical thrombectomy (EVT) has revolutionized management of this most devastating type of ischemic stroke by allowing removal of the occlusive clot. However, about half of the successfully EVT-treated patients (\~85% of all treated patients) still remain disabled at 90 days. Early evidence suggests that patients with lower blood pressure (BP) after the thrombectomy procedure have better outcomes. However, safety of lowering BP in these patients has not been determined. The primary safety concern of lowering BP comes from the potential of compromising blood flow to the "at risk" area of the brain following the stroke. The purpose of this trial is to evaluate the safety of lower BP management strategies in patients who are successfully treated with endovascular treatment for ischemic stroke. The investigator will enroll 120 individuals who qualify and randomly assign them to one of the three systolic BP (SBP) targets: ≤180 mmHg, \<160 mmHg, and \<140 mmHg (40 patients in each group). Treatment will begin soon after the blood clot causing the stroke is removed, using anti-hypertensive medication given intravenously with a goal to lower and maintain the SBP below assigned target for 24 hrs. The scientists will assess the safety of lower BP targets (\<160 mmHg and \<140 mmHg) by quantifying the volume of stroke measured with an MRI scan obtained at 36+/-12 hours and participants' functional status at 90 days measured with a patient centered disability score. Participants will undergo the 36 +/-12-hour MRI scan as part of their routine clinical care and will not be asked to prolong their hospital stay for study purpose. A phone interview will take place to determine their functional status at 90-days. Enrollment of 120 patients will provide 80% power to detect a 10 cubic centimeter increase in stroke volume and a 0.10 decrease in utility-weighted modified Rankin score (a patient-centered disability score) for every 20 mmHg decrease in SBP. An interim analysis will be conducted after enrollment of 60 patients at which time the study may stop for safety concerns.
Investigators
Eva A. Mistry
Assistant Professor
University of Cincinnati
Eligibility Criteria
Inclusion Criteria
- •Adult patients (≥18 years)
- •Undergoing successful EVT (defined as modified Thrombolysis in Cerebral Ischemia Score, mTICI, ≥2b) for an occlusion in the anterior cerebral circulation large vessel (internal carotid artery and M1 or M2 segments of the middle cerebral artery).
- •Intervention will be initiated only for those with a successful recanalization (modified Thrombolysis in Cerebral Ischemia Score ≥ 2b).
- •Undergoing a baseline CT or MR perfusion study
- •Those with unsuccessful recanalization (mTICI 0-2a) will be not intervened upon.
Exclusion Criteria
- •Known heart failure with ejection fraction \<30%
- •Presence of a left ventricular assist device
- •Patients undergoing extracorporeal membrane oxygenation
- •Pregnancy
- •Enrollment in any other clinical trial
Arms & Interventions
Higher Systolic Blood Pressure (SBP) Target
Lower systolic blood pressure to ≤180 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain ≥160 mmHg.
Intervention: Hydralazine
Higher Systolic Blood Pressure (SBP) Target
Lower systolic blood pressure to ≤180 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain ≥160 mmHg.
Intervention: Nicardipine
Higher Systolic Blood Pressure (SBP) Target
Lower systolic blood pressure to ≤180 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain ≥160 mmHg.
Intervention: Labetalol
Lower SBP (<160 mmHg) Target
Lower systolic blood pressure to \<160 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain \>140 mmHg.
Intervention: Nicardipine
Lower SBP (<160 mmHg) Target
Lower systolic blood pressure to \<160 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain \>140 mmHg.
Intervention: Labetalol
Lower SBP (<160 mmHg) Target
Lower systolic blood pressure to \<160 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain \>140 mmHg.
Intervention: Hydralazine
Lower SBP (<140mmHg) Target
Lower systolic blood pressure to \<140 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain \>110 mmHg.
Intervention: Nicardipine
Lower SBP (<140mmHg) Target
Lower systolic blood pressure to \<140 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain \>110 mmHg.
Intervention: Labetalol
Lower SBP (<140mmHg) Target
Lower systolic blood pressure to \<140 mmHg and maintain for 24 hours. If anti-hypertensive medication used, then maintain \>110 mmHg.
Intervention: Hydralazine
Outcomes
Primary Outcomes
Final Infarct Volume
Time Frame: 36 (+/-12) hrs after treatment initiation
Infarct volume on diffusion-weighted MRI (or CT if MRI cannot be obtained) at 36 (+/-12) hrs after treatment initiation, adjusted for the baseline CT perfusion core infract volume.
Utility-weighted Modified Rankin Score
Time Frame: 90 days after treatment initiation
Modified Rankin score (mRS) is a scale for measuring the degree of disability or dependence of people who have suffered a stroke. 0 - no symptoms at all; 1 - no significant disability despite symptoms; able to carry out all usual duties and activities; 2- slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance; 3- moderate disability; requiring some help, but able to walk without assistance; 4 - moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance; 5 - severe disability; bedridden, incontinent and requiring constant nursing care and attention; 6- dead. Patient centered utility weights are applied to these scores as 1.0 for mRS level 0; 0.91 for mRS level 1; 0.76 for mRS level 2; 0.65 for mRS level 3; 0.33 for mRS level 4; 0 for mRS level 5; and 0 for mRS level 6. Unlike the mRS, the utility-weighted mRS runs from 0 to 1, with 0 being the worst.
Secondary Outcomes
- Number of Participants With Neurological Worsening Associated With Antihypertensive Treatment(Treatment initiation to 24 hrs after treatment initiation)
- Number of Participants With Symptomatic Hemorrhagic Transformation(36(+/-12) hrs after treatment initiation)
- Number of Participants With Any Hemorrhagic Transformation(36(+/-12) hrs after treatment initiation)