Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals

Not Applicable

Completed

• Conditions: Obesity; Inflammation

• Registration Number: NCT00416156
• Lead Sponsor: Taichung Veterans General Hospital

Brief Summary

To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-05
• Study Completion: 2005-11
• Status Verified: 2006-12
• Study First Submitted: 2006-12-25
• Study First Submitted QC: 2006-12-26
• Last Update Submitted: 2006-12-26
• Study First Posted: 2006-12-27
• Last Update Posted: 2006-12-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Nondiabetes obese individuals with BMI greater than 27 kgs/m2

Exclusion Criteria

• Diabetes
• Abnormal hepatic, renal and cardiac function

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Inflammatory responses after weight reduction

Secondary Outcome Measures

Name	Time	Method
BMI
Circulating inflammatory markers
Adipocytokines
Gene Expression from mononuclear cells

Trial Locations

Locations (1)

Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwan