Cerebral Magnetic Resonance Imaging in active Crohn*s Disease patients with fatigue

Recruiting

• Conditions: cerebrale metabole veranderingen; fatique; cerebral metabolism; 10017969

• Registration Number: NL-OMON38079
• Lead Sponsor: MD

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Women age18-40 years
Crohn*s Disease patients with active bowel disease (Harvey Bradshaw Index, HBI>4) and fatigue with a numerical rating scale (NRS) of 6 or more (on an 11-point NRS)
Endoscopic or histological proven Crohn*s disease at least 3 months before inclusion
Healthy persons, without cerebral or central nervous system disease or other chronic inflammation in the body

Exclusion Criteria

Comorbidity for fatigue: e.g. anemia (Hb< 7,0 mmol/L or ferritine < 10 ug/L)
Routine MRI-contraindications (e.g. instable metal implants, pacemaker/ICD, vascular clips)
TNF-alpha treatment, methotrexate within 12 weeks before inclusion
Pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>the presence of:<br /><br>Elevated levels of choline<br /><br>cerebral structural changes</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>