Efficacy of Low Dose Levothyroxine During Pregnancy
- Registration Number
- NCT03391154
- Lead Sponsor
- Ain Shams University
- Brief Summary
the effect using low dose levo thyroxine in pregnant females with TSH level more than 2.5 mU/L in the first trimester on pregnancy outcome
- Detailed Description
the study aim to detect the effect of low dose levothyroxine 50 ug on pregnant females and compare it with others receiving placebo
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 180
Inclusion Criteria
- females with TSH more than 2.5 mU/L and less than 4 mU/L after biochemical diagnosis of pregnancy.
Exclusion Criteria
- associated endocrinopathies (PCO/ DM/ hyperprolactinemia )
- associated medical condition (HTN/ chronic kidney disease.
- history of recurrent pregnancy loss
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description levothyroxine levothyroxin 100 pregnant female with TSH of\> 2.5 mU/L but less than 4 mU/L after biochemical diagnosis of pregnancy will receive 50 ug of levothyroxine (eltroxin 50) aspen,Egypt throughout the pregnancy
- Primary Outcome Measures
Name Time Method 1st trimester miscarriage during 1st 13 weeks of pregnancy 1st trimester spontaneous or missed abortion
- Secondary Outcome Measures
Name Time Method adverse pregnancy outcome last 26 week of gestation 2nd trimesteric missed or spontaneous abortion ,gestational hypertension,preeclampsia, anemia, abruptio placenta premature delivery , fetal growth restriction, low birth weight
Trial Locations
- Locations (1)
AinShams university maternity hospital
🇪🇬Cairo, Abbassya, Egypt