Short-term effects on blood pressure of reducing nitrate metabolism using antibacterial mouthwash in treated hypertensive individuals

The University of Western Australia0 sites25 target enrollmentApril 15, 2013

Overview

No summary available.

Registry

who.int

Start Date

April 15, 2013

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•\* Men and women will be aged between 50 and 70 years
•\* Regular use of at least one antihypertensive medication for elevated blood pressure
•\* Clinic/office systolic blood pressure will be \>120 mmHg

•\* Use of more than 3 antihypertensive medications
•\* A change in antihypertensive medication within the past 1 month
•\* Inability to attend clinic/office visits
•\* Clinic/office systolic blood pressure greater than 160 mm Hg or less than 120 mm Hg; or diastolic blood pressure greater than 100 mm Hg;
•\* Use of antibiotics (within previous 1 months);
•\* current or recent (\<6 months) smoking;
•\* body mass index \< 18 or \> 35 kg/m2;
•\* current cardiovascular or peripheral vascular disease, or diagnosed diabetes, or history of a cardiovascular event;
•\* a psychiatric illness, or presence of other major illnesses such as cancer;
•\* current or recent (within previous 6 months) significant weight loss or gain (\> 6% of body weight);