Short-term effects on blood pressure of reducing nitrate metabolism using antibacterial mouthwash in treated hypertensive individuals

Completed

• Conditions: Cardiovascular disease; Hypertension; Cardiovascular - Hypertension; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12613000417785
• Lead Sponsor: The University of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

* Men and women will be aged between 50 and 70 years
* Regular use of at least one antihypertensive medication for elevated blood pressure
* Clinic/office systolic blood pressure will be >120 mmHg

Exclusion Criteria

* Use of more than 3 antihypertensive medications
* A change in antihypertensive medication within the past 1 month
* Inability to attend clinic/office visits
* Clinic/office systolic blood pressure greater than 160 mm Hg or less than 120 mm Hg; or diastolic blood pressure greater than 100 mm Hg;
* Use of antibiotics (within previous 1 months);
* current or recent (<6 months) smoking;
* body mass index < 18 or > 35 kg/m2;
* current cardiovascular or peripheral vascular disease, or diagnosed diabetes, or history of a cardiovascular event;
* a psychiatric illness, or presence of other major illnesses such as cancer;
* current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight);
* alcohol intake > 210 g per wk for women and > 280 g per wk for men;
* pregnant or lactating women;
* inability or unwillingness to consume beverages provided.

Study & Design

• Study Type: Interventional
• Study Design: Not specified