Class III Obesity and Periodontitis: Gingival Crevicular Fluid of Adiponectin and Resistin As Predictable Implement in Staging and Grading System and Effects of Periodontal Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- adiponectin level in gingival crevicular fluid
研究概览
简要总结
The goal of this clinical trial is to evaluate the relationship between obesity and gingival crevicular fluid resistin and adiponectin in periodontitis patients as well as assess the effect of non-surgical periodontal therapy on their levels using ELISA in obese individuals. Researchers will compare different stages of periodontitis to see if degrees of inflammation and periodontal therapy related obesity
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •obese persons with Body Mass Index (BMI) more than 40 and suffering from periodontitis
排除标准
- •Patients receiving either antibiotics or non-steroidal anti- inflammatory at least 3 months prior to samples collection.
- •Patients subjected to previous periodontal therapy 6 months before sampling. Patients with systemic or local inflammatory conditions other than periodontal disease.
- •Neither lactating nor pregnant.
研究组 & 干预措施
mild periodontitis (first stage, grade B)
mild periodontitis (first stage, grade B) manifesting CAL ≥ 1-2 mm, in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants.
干预措施: non-surgical full-mouth periodontal therapy without using adjunct disinfectants (Procedure)
mild periodontitis (first stage, grade B)
mild periodontitis (first stage, grade B) manifesting CAL ≥ 1-2 mm, in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants.
干预措施: GCF level of adiponectin and resistin (Diagnostic Test)
moderate periodontitis (second stage, grade B)
moderate periodontitis (second stage, grade B) manifesting CAL ≥ 3-4mm in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants.
干预措施: non-surgical full-mouth periodontal therapy without using adjunct disinfectants (Procedure)
moderate periodontitis (second stage, grade B)
moderate periodontitis (second stage, grade B) manifesting CAL ≥ 3-4mm in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants.
干预措施: GCF level of adiponectin and resistin (Diagnostic Test)
severe periodontitis (third stage, grade B)
severe periodontitis (third stage, grade B) manifesting CAL ≥ 5mm , in corporation with BoP increased than (30%), percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants
干预措施: non-surgical full-mouth periodontal therapy without using adjunct disinfectants (Procedure)
severe periodontitis (third stage, grade B)
severe periodontitis (third stage, grade B) manifesting CAL ≥ 5mm , in corporation with BoP increased than (30%), percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants
干预措施: GCF level of adiponectin and resistin (Diagnostic Test)
very severe periodontitis (forth stage, grade C)
very severe periodontitis (forth stage, grade C) manifesting CAL ≥ 5mm in corporation of percentage of bone loss level divided by age more than 1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants
干预措施: non-surgical full-mouth periodontal therapy without using adjunct disinfectants (Procedure)
very severe periodontitis (forth stage, grade C)
very severe periodontitis (forth stage, grade C) manifesting CAL ≥ 5mm in corporation of percentage of bone loss level divided by age more than 1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants
干预措施: GCF level of adiponectin and resistin (Diagnostic Test)
结局指标
主要结局
adiponectin level in gingival crevicular fluid
时间窗: From enrollment to the end of treatment results assessment at 12 weeks
resistin level in gingival crevicular fluid
时间窗: From enrollment to the end of treatment results assessment at 12 weeks
次要结局
- O'Leary Plaque score(From enrollment to the end of treatment results assessment at 12 weeks)
- bleeding on probing percentage (BoP)(From enrollment to the end of treatment results assessment at 12 weeks)
- clinical attachment level (CAL)(From enrollment to the end of treatment results assessment at 12 weeks)
- probing pocket depth(From enrollment to the end of treatment results assessment at 12 weeks)
研究者
Asem Mohammed Kamel Ali
lecturer
Al-Azhar University