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Clinical Trials/NCT04635163
NCT04635163CompletedNot Applicable

Ideation Trajectories and Suicide Attempts in Adolescents With Psychiatric Disorders in the Maule Region. Chile

Universidad Católica del Maule1 site in 1 country388 target enrollmentStarted: March 19, 2018Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
388
Locations
1
Primary Endpoint
Suicidal ideation and previous attempts versus single attempt

Study Overview

Brief Summary

This project seeks to evaluate the trajectories of suicidal ideation and attempts in adolescent patients with psychiatric disorders in secondary care controls in the Maule region, in relation to clinical factors (depressive symptoms, anxiety, stress, psychiatric comorbidity, mistreatment or abuse, history of psychiatric disorders and pharmacological treatments); psychological (parenting styles, impulsivity, barriers in seeking help and emotional regulation), and neuropsychological (executive function-decision making).

Detailed Description

Background

Adolescent suicide is a major problem in public health worldwide and due to the multi-dimensionality of factors involved (biological, genetic, psychiatric, economic, socio-demographic, family-related and cultural), its study is complex. Within the general population, the global suicide rate is 10.6 deaths for every 100,000 inhabitants (13.5 men and 7.7 women) and in the Americas it comes up to 9.8 deaths for every 100,000 inhabitants (15.1 men and 4.6 women). In Chile, the suicide rate is 10.6 deaths for every 100,000 inhabitants (17.2 men and 4.0 women) being above average regarding other countries in the Americas.

For adolescents, suicide is the second cause of premature death among people ranging from 15 to 29 and the third for the 15-19 age group. Also, within the group of 10 to 24 there are more deaths from suicide than traffic accidents, cancer, and cardiac diseases. In Chile, 60% of deaths among adolescents are caused by external reasons (suicide and homicide). Deaths to suicide among Chilean adolescents have presented a sustained increase in the last 15 years (55% between 1999-2005), being the second country within the Organization for Economic Co-operation and Development (OECD) with the highest percentage variation. In a recent study which compared the suicide rate among adolescents from 10 to 19 in countries belonging to the OECD, Chile had the fourth highest suicide rate with 5.36 deaths for every 100,000 inhabitants. When divided into sub-groups, Chile had the highest rates from 10 to 14 in both men and women with 2.23 deaths for every 100,000 inhabitants; and in the group of 15 to 19 the third highest rates in males and the fourth in females with 15.87 and 6.32 deaths for every 100,000 inhabitants, respectively.

Adolescence is a critical period of vulnerability for the development of suicidal behavior. During this stage, suicidal behavior shows unstable and fluctuating patterns; ideation without suicide attempts may appear, subjects can go from ideas to plans and make an attempt, there are those who try just once while others try repeatedly, and there are others who, in spite of their vulnerability, do not develop such behavior. Suicide rates vary according to gender and age, being higher among men than women, while ideation and suicide attempts are more frequent among women rather than men. It is estimated that for each completed suicide in young people, there are from 100 to 200 suicide attempts. Also, suicidal thoughts have been associated to later attempts and their repetition. It is estimated that a third of adolescents with suicidal thoughts will try during the following year. Evidence shows that lifetime the suicidal ideation rate is 12.1% in adolescents from 13 to 18; on the other hand, 7.4% of young people from 10 to 24 have reported at least one suicide attempt within the last 12 months with a greater prevalence of attempts among women (9.3%) than men (5.1%). In Chile, 23.7% of adolescents ranging from 13 to 18 presented suicidal ideation and 9% tried in the last 12 months.

The Chilean Health Ministry [MINSAL in Spanish] projected a rate of 12 deaths for every 100,000 inhabitants for adolescents from 10 to 19 for the year 2020. According to the sanitary objectives for the 2011-2020 decade, the MINSAL got determined to diminish this projected rate by 15%. However, in Chile there are still various limitations and challenges regarding the study of suicidal behavior among adolescent population. Considering the risk of onset of suicidal thoughts and attempts during adolescence and the variability in their evolution, it becomes necessary to make an early and timely identification of high-risk clinical sub-groups. The analysis of both their patterns along a timeframe and the influence and interaction of specific factors could meet such objective.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
15 Years to 19 Years (Child, Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Suicidal ideation and previous attempts versus single attempt

Time Frame: 3 years

Adolescents with suicidal ideation and previous attempts will be more likely to repeat than those with a single attempt.

Clinical and psychological factors, predispose irregular course of suicidal thoughts and scant seek for help.

Time Frame: 3 years

Adolescents with less emotional regulation, poor parenting styles, high levels of impulsivity and a history of self-harm will have significant differences in levels of suicidal ideation during the follow-up period (3 measurements) and more than 60% of them will report that they do not seek help to deal with your mental health problems.

High levels of suicidal ideation and likelihood of suicide attempts during the follow-up period

Time Frame: 3 years

High levels of suicidal ideation at first measurement, predicts a higher likelihood of suicide attempts during the follow-up period.

Severity of suicidal ideation according to psychiatric comorbidity, impaired decision-making capacity, and previous suicide attempts.

Time Frame: 3 years

Adolescents with previous suicide attempts, psychiatric comorbidity, and impaired decision-making capacity, have a greater severity of suicidal ideas, and consequently, are more likely to repeat a suicide attempt than those without these characteristics.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Pablo Méndez-Bustos, Ph.D.

Principal Investigator

Universidad Católica del Maule

Study Sites (1)

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