Metoclopramide, versus it’s combination with dexamethasone in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a double-blind randomized controlled trial

Phase 4

Completed

• Conditions: GallstonesGallbladder polyp; Metoclopramide; Dexamethasone; Postoperative nausea and vomiting (PONV); Laparoscopic cholecystectomy

• Registration Number: TCTR20140128001
• Lead Sponsor: Royal College of Surgeons of Thailand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-12-09
• Study Start: 2014-01-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patients with American Society of Anaesthesiologists physical status classification (ASA) 1-2.
2. Patients requiring elective laparoscopic cholecystectomy.

Exclusion Criteria

1. Pregnancy
2. Breast feeding
3. History of motion sickness
4. Nausea/vomiting use of antiemetics within 24 hrs prior to surgery
5. Insulin-dependent DM
6. Allergy to any protocol medication
7. Conversion to open cholecystectomy
8. Development of intraoperative complication
9. Contraindication for dexamethasone: tuberculosis, herpes simplex virus of ophthalmic
10. Contraindication for metoclopramide: epilepsy, pheochromocytoma, antipsychotic (haloperidol, chlorpromazine) treated patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative nausea and vomiting Postoperative period after laparoscopic cholecystectomy Incidence

Secondary Outcome Measures

Name	Time	Method
Postoperative pain Postoperative period after laparoscopic cholecystectomy Pain score