Exploratory clinical study of pravastatin therapy as a medical treatment for unruptured vertebral artery dissectio
- Conditions
- Diseases of the circulatory system
- Registration Number
- KCT0003597
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 34
? Patients of korean nationality over 20 years old and under 75 years old
? In the last 4 weeks, mildly and medically controlled symptoms occured, excluding hemorrhage and cerebral infarction of a moderate degree or severe, and unruptured vertebral artery dissection related to symptoms is radiologically identified
? Vertebral artery dissection in V3 or V4 segments
? Patients who agreed with this study
? Vertebral artery dissection with hemorrhagic or moderate to severe ischemic cerebral infarction
? Patients with diabetes or other vascular endothelial abnormalities
? Patients who are currently taking statin or lipid lowering drugs for dyslipidemia or cardiovascular disease
? Patients who had previous endovascular treatment or surgery or radiotherapy in or near the lesion
? Patients with significant underlying disease or active infection or severe trauma
? Patients with poor medication compliance
? Patients with past history of pravastatin, aspirin-induced hypersensitivity and adverse events
? Patients with galactose intolerance, lactose intolerance, Glucose-galactose malabsorption and genetic problem with paravastatin
? severe liver failure(liver cirrhosis) or renal failure(eGFR < 30 ml/min/1.7 m2)
? Patients with past history of myopathy including rhabdomyolysis
? Women who are pregnant or possibly pregnant or who are lactating
? Heavy drinker
? Patients with hemophilia or with bleeding tendency or treated with peptic ulcer
? Patients taking medication which is contraindication of comedication drugs with pravastatin, aspirin or has drug-drug interaction with pravastatin, aspirin
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparative evaluation of the radiologic changes of unruptured vertebral artery dissection on magnetic resonance imaging(MRI) for 6 months compared with MRI performed at the first visit.
- Secondary Outcome Measures
Name Time Method Clinical symptoms;Evaluation of Low-density lipoprotein(LDL) in blood;Evaluation of C-reactive protein(CRP) in blood