DRKS00000723已完成1 期

Regeneration in acute stroke - RAIS

Klinik für Neurologie, Universität Regensburg, Bezirksklinikum Regensburg0 个研究点目标入组 22 人开始时间: 2011年2月22日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Acute ischemic stroke with NIHSS 4-22
•middle cerebral artery territory (M2-branch occlusion);
•- dominant and non-dominant hemisphere
•- Informed and written consent
•- inclusion into study within 12hrs of symptom onset
•- age = 18 yrs = 60 yrs
•- normal liver function (transaminases such as GOT, GPT, ?GT) not exceeding 3x of normal values, bilirubin < 1.5 mg/dl
•- normal bone marrow function (platelets and leucocytes within normal range)
•- good expected compliance

•- treatment with abciximab (Rheopro (R))
•- IV thrombolysis in the past 14 days but not IV thrombolysis for current event
•- participant in any other investigational study
•- global aphasia
•- expected operation within the next days
•- interal carotid artery pseudoocclusion or ulcerated carotid plaque
•- suspected vasculitis
•- dissection of brain supplying arteries
•- pregnancy
•- residual neurologic deficit from previous stroke (either hemorrhagic or ischemic)
•- immunosuppressive therapy (such as glukocorticoids)
•- hematologic disease (such as myeloproliferative disease)
•- platelet dysfunction
•- non-controlled metabolic state (such as diabetes or hyperlipidemia)
•- uncontrolled arterial hypertension
•- any coagulation disorder
•- severe coronary artery disease
•- spheroid cell anemia
•- any severe ongoing malignant disease
•- severe psychiatric disorder (depression, psychosis, addictive syndromes)
•- high grade myocardial insufficiency
•- positive for HIV
•- any malignant cancer
•- known allergy against G_CSF
•- heavy smoking, more than 20 cigarettes per day

发起方

Klinik für Neurologie, Universität Regensburg, Bezirksklinikum Regensburg