Rehabilitating (stroke-induced) Apraxia with direct Current Stimulatio

Not Applicable

• Conditions: Apraxia after left hemisphere stroke; I63; R48.2; Cerebral infarction; Apraxia

• Registration Number: DRKS00012292
• Lead Sponsor: niversität zu Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-01
• Study Completion: 2021-11-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 117

Inclusion Criteria

Left hemispheric ischemic stroke in subacute/ chronic phase (>10 days and <180 days post-stroke);
Clinical confirmation of apraxia by KAS (Cologne Apraxia Screening), Cut-off = 76/ 80 points;
Age 18 - 90 years;
written informed consent

Exclusion Criteria

Pregnancy, breastfeeding and women without exclusion of pregnancy;
Patients with clinical manifestation of a stroke prior to the index-stroke;
malignant disease affecting the central nervous system;
epileptic seizure within the past two years;
life expectancy <12 months;
current addiction to alcohol or drugs or other addictive disease (exception: nicotine);
current clinically manifest psychiatric disorders, such as schizophrenia or severe depressive episode;
continuous medication during the intervention phase with benzodiazepine, antipsychotics of high potential and anti-epileptic drugs taken for prophylaxis of epileptic seizures;
enrollment in other studies with brain stimulation in the time period after the index-stroke;
heart pacemaker;
electrodes for deep brain stimulation or other metal implants in the head (expected are dental fillings and inlays); craniectomy or trepanation;
vulnerable skin lesions in electrode positions;
poor motivation/ cooperation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Degree of apraxia, measured 3-4 days after the last stimulation (evaluated by KAS, Cologne Apraxia Screening), compared to baseline.

Secondary Outcome Measures

Name	Time	Method
In the post-interventional assessment 3-4 days after the last stimulation and after 3 months: <br><br>Degree of apraxia (measured by Goldenberg hand- and finger imitation; de Renzi imitation; de Renzi actual tool use),<br><br>Evaluation of strength (grip force vigorimeter; strength of hands by MRC-scale),<br><br>Extent of handicap (modified Ranking Scale, mRS),<br><br>Extent of aphasia (short version of Aphasia-Check-List).<br><br>After 3 months additionally:<br><br>Degree of apraxia (KAS, Cologne Apraxia Screening);<br><br>Movement function (Action Research Arm Test, ARAT; Jebsen-Taylor Hand Function Test, JTHFT).