Research on the efficacy and mechanism of the traditional Chinese medicine treatment of removing phlegm and blood stasis in patients with severe cerebral hemorrhage based on multimodal brain function monitoring technology

Phase 1

• Conditions: Severe intracerebral hemorrhage

• Registration Number: ITMCTR2100004479
• Lead Sponsor: Guangdong Provincial Hospital of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients aged >= 18 years and <= 75 years;
2. Patients with acute cerebral hemorrhage within 72 hours of onset;
3. Patients with severe cerebral hemorrhage: GCS score <= 12 or NIHSS score >= 11;
4. Patients with supratentorial hemorrhage were identified by head CT, and the amount of bleeding was more than 30ml;
5. Patients who signed informed consent.

Exclusion Criteria

1. Patients with cerebral hemorrhage caused by brain tumor, brain trauma, blood disease, cerebral vascular malformation (congenital abnormality) or aneurysm;
2. Patients with liver and kidney dysfunction;
3. For patients with severe disease, the expected survival time is not more than 2 weeks;
4. Patients with GCS score <= 5;
5. Patients who were unable to take care of themselves before stroke (MRS 3-5 points);
6. Subjects who could not complete the follow-up;
7. Patients participating in other clinical trials.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mRs;GCS scores;

Secondary Outcome Measures

Name	Time	Method
Cerebral blood flow;Blood-brain barrier function;The inflammatory response;NIHSS scores;all cause mortality;Cerebral edema volume by CT;hematoma volume by CT;