Postamputation Pain: Peripheral Mechanisms
Overview
- Phase
- Not Applicable
- Intervention
- Lidocaine
- Conditions
- Neuropathic Pain
- Sponsor
- Danish Pain Research Center
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Reduction in spontaneous pain on a Numeric Rating Scale (NRS: 0-10, 0 = no pain, 10 = worst possible pain)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Stump and phantom pain after amputation are common, but the responsible mechanisms are still not clarified. It has been suggested that phantom limb pain can be reduced by regional anaesthesia and in several recent studies, pain was reduced following intrathecal and intraforaminal blocks. In this study, the investigators want to investigate if spontaneous and evoked pain in amputees will be relieved by regional nerve blocks involving the damaged nerves.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Amputees with chronic amputation pain (stump or phantom pain) 3 or above on NRS (numerical ratio scale).
Exclusion Criteria
- •Severe somatic or psychiatric diseases
- •Other peripheral neuropathy
- •Lack of ability to cooperate to the clinical examination
- •Allergy to Lidocaine or similar analgetics
Arms & Interventions
Lidocaine block
Intervention: Lidocaine
Isotonic saline block
Intervention: Placebo
Outcomes
Primary Outcomes
Reduction in spontaneous pain on a Numeric Rating Scale (NRS: 0-10, 0 = no pain, 10 = worst possible pain)
Time Frame: From 0 minutes until 120 minutes after injection
The patient will be asked about spontaneous pain, including stump and phantom pain on a Numerical Rating Scale (NRS: 0-10, 0 = no pain, 10 = worst pain).
Secondary Outcomes
- Reduction in evoked pain on a Numerical Rating Scale (NRS: 0-10, 0 = no pain, 10 = worst possible pain).(From 0 minutes until 120 minutes after injection)