Can Enhanced Glycaemic Control in Type II Diabetics Improve Myocardial Protection During Coronary Artery Bypass Grafting?
Overview
- Phase
- Not Applicable
- Intervention
- Glucose potassium insulin solution
- Conditions
- Type 2 Diabetes
- Sponsor
- University Hospital Birmingham
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- The difference in the mean left ventricular end-systolic volume index (LVESVI) after CABG and the amount of new permanent injury detected in the late CMRI study
- Last Updated
- 16 years ago
Overview
Brief Summary
The investigators have previously demonstrated that the administration of insulin in the form of an infusion with additional sugar and potassium may improve cardiovascular performance and reduce biochemical evidence of heart muscle injury in non-diabetic patients undergoing coronary artery surgery. The investigators now seek to demonstrate that similar benefits can be achieved in diabetic patients by administering insulin to maintain as near absolutely normal sugar levels as possible.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Type II diabetes mellitus patients (as defined by WHO)
- •Diet, oral hypoglycaemic or insulin therapy
- •Undergoing elective and urgent coronary artery bypass surgery
Exclusion Criteria
- •Non-diabetics
- •Emergency and redo CABG
- •\< 18 years
- •Pregnancy
- •Dialysis-dependence
- •History of CVA/TIA \< 6 months
- •Heart valve disease requiring surgery
- •STEMI \< 3 months
Arms & Interventions
1
Administered with glucose potassium insulin solution to achieve euglycaemia 4.0-6.0 mmol/L
Intervention: Glucose potassium insulin solution
Outcomes
Primary Outcomes
The difference in the mean left ventricular end-systolic volume index (LVESVI) after CABG and the amount of new permanent injury detected in the late CMRI study
Time Frame: 3 months post CABG
Secondary Outcomes
- Glycaemic control will be assessed 2 hours pre-operatively and 72 hours post-operatively. Measurement timings will be standardized allowing comparison of glycaemic control during different time-periods.(72 hours post CABG)