The Effect of Home-based Exercise on Functional Capacity of Covid-19 Survivor With Cardiovascular Comorbidity
- Conditions
- Covid19Breathing ExerciseCardiovascular Diseases
- Interventions
- Behavioral: Second phase cardiac rehabilitationBehavioral: Breathing and chest mobilization exercises
- Registration Number
- NCT05077943
- Lead Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
- Brief Summary
Objective propose: to investigate the effect of home based breathing exercise and chest mobilization on the cardiorespiratory functional capacity of Covid-19 survivors with cardiovascular comorbidity.
Breathing exercise and chest mobilization are proven to increase lung functional capacity in Covid-19 survivors. It is hypothesized that breathing exercise and chest mobilization in Covid-19 survivors will give benefits to Covid-19 survivors with cardiovascular disease.
- Detailed Description
Lung restrictive disorder is one of the reasons that induce chronic fatigue in COVID-19 (Corona Virus Disease-19) survivors. It also gives a significant effect on cardiovascular patients who are in the second phase of cardiac rehabilitation. Breathing exercise and chest mobilization are proven to increase lung functional capacity in Covid-19 survivors. On the other hand, there is still no research that shows the effectiveness of Breathing exercises and chest mobilization in Covid-19 survivors who are suffering from cardiovascular problems.
Patients in National Cardiac Center Hospital, Jakarta, with a history of Covid-19 and have cardiovascular disease are recruited. They will undergo pre and post-exercise examinations such as blood sampling, do 6 minutes walking test, Peak Cough Flow and Peak Flow Rate test, measuring the chest dimension, treadmill, and answer the European Quality of Life Five Dimension (EQ-5D) questions. With randomization, patients will be determined to treatment or control group. They will be prepared about what exercises should they do at home. Subjects will be supervised digitally and regularly through Zoom meetings. Exercises will be done for 3 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 46
- Patients who got infected by Covid-19 in 3 months before recruitment and suffering cardiovascular disease
- Able to communicate and operate Youtube and Zoom.
- Limitation to move any part of the body that causes the inability to do the instructed exercise.
- Feel pain in extremities (visual analog scale >3)
- Chronic Obstructive Pulmonary Disease
- Neuromuscular disorder (stroke, peripheral neuropathy with significant motoric control disturbance
- Musculoskeletal disorder (fracture, post amputation, severe arthritis in support joints)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description No Breathing Exercise Second phase cardiac rehabilitation Patients will do the second phase of cardiac rehabilitation for minimum 5 times per week, 30 minutes each time, in 3 months without being supervised With Breathing Exercise Breathing and chest mobilization exercises Patients will do the second phase of cardiac rehabilitation for minimum 5 times per week, 30 minutes each time and breathing and chest mobilization exercise for 3 times per week. They will be supervised through online meetings.
- Primary Outcome Measures
Name Time Method Change of 6-minutes walking test Change from Baseline 6-minutes walking test at 3 months To define initial ability to walk in 30 minutes for second phase cardiac rehabilitation (aerobic exercise). Unit of measure : meter
Change of Cardiac Exercise Test Change from Baseline Cardiac Exercise Test at 3 months Patients walk on treadmill. Unit of measure : minutes, METs (Metabolic Equivalent of Task)
Change of Peak Cough Flow (PC) Change from Baseline Peak Cough Flow (PC) at 3 months to define the functional capacity. Unit of measure : L/min.
Change of Peak Flow Rate (PFR) Change from Baseline Peak Flow Rate (PFR) at 3 months to define the functional capacity. Unit of measure : L/min.
- Secondary Outcome Measures
Name Time Method Change of Lymphocyte Change from Baseline Lymphocyte at 3 months Lymphocyte (/µL)
Change of C-Reactive Protein Change from Baseline C-Reactive Protein at 3 months to determine infection markers. Unit of measure : mg/L
Change of Mean Corpuscular Hemoglobin Change from Baseline Mean Corpuscular Hemoglobin at 3 months Mean Corpuscular Hemoglobin (pg)
Change of Neutrophil Change from Baseline Neutrophil at 3 months Neutrophil (/µL)
Change of Hematocrit Change from Baseline Hematocrit at 3 months Hematocrit (%)
Change of Mean Corpuscular Volume Change from Baseline Mean Corpuscular Volume at 3 months Mean Corpuscular Volume (fL)
Change of Platelet Change from Baseline Platelet at 3 months Platelet (thousand/µL)
Change of Hemoglobin Change from Baseline Hemoglobin at 3 months Hemoglobin (g/dL)
Change of Erythrocyte Change from Baseline Erythrocyte at 3 months Erythrocyte (million/µL)
Change of European Quality of Life Five Dimension (EQ-5D) Change from Baseline EQ-5D at 3 months 1=have no problem, 2=have slight problem, 3=moderate problem, 4=severe problem, 5=unable to do. We will compare the points between pre and post exercise and looking the improvement.
Change of Eosinophil Change from Baseline Eosinophil at 3 months Eosinophil (/µL)
Change of Monocyte Change from Baseline Monocyte at 3 months Monocyte (/µL)
Change of Mean Corpuscular Hemoglobin Concentration Change from Baseline Mean Corpuscular Hemoglobin Concentration at 3 months Mean Corpuscular Hemoglobin Concentration (%)
Change of Red Cell Distribution Width Change from Baseline Red Cell Distribution Width at 3 months Red Cell Distribution Width (%)
Change of Leucocyte Change from Baseline Leucocyte at 3 months Leucocyte (/µL)
Change of D-dimer Change from Baseline D-dimer at 3 months Unit of measure : ng/mL
Change of Basophil Change from Baseline Basophil at 3 months Basophil (/µL)
Trial Locations
- Locations (1)
National Cardiovascular Center Harapan Kita Hospital Indonesia
🇮🇩Jakarta, Indonesia