48-hour Ambulatory EEG Monitoring in Early Onset Alzheimer's Disease

Not Applicable

Recruiting

• Conditions: Early Onset Alzheimer Disease
• Interventions: Diagnostic Test: Computer assisted ambulatory electroencephalogram

• Registration Number: NCT04002583
• Lead Sponsor: Mayo Clinic

Brief Summary

Researchers are trying to determine the frequency of seizures and epilepsy in patients with Early-onset Alzheimer's disease (EOAD) using a 48-hour computer assisted ambulatory electroencephalogram.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-06-27
• Study First Submitted QC: 2019-06-27
• Study First Posted: 2019-06-28
• Study Start: 2020-02-19
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-25
• Last Update Posted: 2025-03-28
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

• Meets core clinical criteria for non-AD dementia.
• Two or more first degree relatives with a history of EOAD suggestive of autosomal dominant transmission, unless known pathogenic mutations in APP, PSEN1, PSEN2 have been excluded.
• Known mutation in an ADAD gene (APP, PSEN1, PSEN2) or other autosomal dominant genes associated with other neurodegenerative disorders.
• MRI scans with evidence of infection or focal lesions, cortical strokes, multiple lacunes (single lacune is allowable unless it meets criteria for strategic lacune affecting cognition)
• Any significant systemic illness or unstable medical condition, which could lead to difficulty complying with the protocol (at the discretion of the Site PI)
• Medical history of a brain disorder other than the disorder causing dementia except for headache.
• Deemed ineligible by the Site PI for any other reason.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Early-onset Alzheimer's disease (EOAD) subjects	Computer assisted ambulatory electroencephalogram	Subjects with mild cognitive impairment due to EOAD will undergo a 48 hour computer assisted ambulatory electroencephalogram

Primary Outcome Measures

Name	Time	Method
Electrographic seizures: Number of subjects with electrographic seizures	48 hours	Number of subjects with electrographic seizures in 48 hours on computer assisted ambulatory EEG

Trial Locations

Locations (1)

Mayo Clinic in Florida; 🇺🇸 Jacksonville, Florida, United States