Comparing chest trauma severity scoring with levels of circulating mitochondrial dna as prognostic marker in chest trauma patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To Compare Chest Trauma Severity Scoring with Levels of Circulating DNA as a
研究概览
简要总结
This study aims to evaluate whether levels of mitochondrial DNA in the blood can serve as a reliable prognostic marker in patients with chest trauma. The researchers compare standard chest trauma severity scoreswith circulating mtDNA levels, to see how well each predicts clinical outcomes such as complications, ICU stay, or mortality.
Patients presenting with chest trauma are assessed using established severity scoring systems e.g., AIS, ISS. At the same time, blood samples are collected to measure mtDNA levels. The relationship between trauma severity, mtDNA concentration, and patient outcomes is analyzed to determine if mtDNA can enhance or replace existing scoring tools for prognosis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patient admitted to the emergency department within 24 hours 2.Patients with clinical symptoms and pulmonary infiltrative shadows 3.Patients requiring mechanical ventilation support 4.Patients with chest trauma with trauma as a causative factor; confirmation of blunt trauma based on clinical evaluation and diagnostic imaging (e.g., chest x-ray, ct scan) 5.Availability of blood samples for mitochondrial dna (mtdna) analysis at the time of admission or shortly thereafter 6.Written informed consent obtained from patients or legally authorized representatives for participation in the study.
排除标准
- •Patients with penetrating chest trauma (e.g., gunshot wounds, stab wounds) as the primary mechanism of injury.
- •Patients with pre-existing medical conditions or comorbidities known to affect mtDNA levels or alter prognostic outcomes (e.g., chronic inflammatory disorders, mitochondrial diseases).
- •Patients with severe traumatic brain injury or other injuries requiring immediate surgical intervention, potentially confounding the assessment of blunt chest trauma outcomes.
- •Patients with history of Chronic lung disease, Autoimmune diseases, infections 4) Patients with history of Lung Surgery 5) Patients with ARDS with Non-Traumatic causes 6) Patients with active Bleeding conditions Patients with incomplete medical records or missing data necessary for the evaluation of clinical outcomes and severity scoring.
- •Pregnant patients, as pregnancy-related changes in mtDNA levels could introduce confounding variables in the analysis.
- •Patients who decline or are unable to provide informed consent for participationPatients transferred from other healthcare facilities with incomplete documentation of injury mechanism or clinical management prior to arrival.
- •in the study.
结局指标
主要结局
To Compare Chest Trauma Severity Scoring with Levels of Circulating DNA as a
时间窗: 1. Day of Admission( Day 1) | 2. 3 rd Day | 3. 7 th day
prognostic Marker
时间窗: 1. Day of Admission( Day 1) | 2. 3 rd Day | 3. 7 th day
次要结局
- 1) 28 days Mortality(2) Ventilatory Free days)