Carotid Intima-media Thickness and Coronary Flow Reserve as Cardiovascular Event and Mortality Predictors in Peritoneal Dialysis Patients: Results of Seven-year Follow-up From a Single Center
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- Diseases morbidity
研究概览
简要总结
Cardiovascular (CV) disease is the main cause of death in patients on dialysis. The aim of this study is the long-term prognostic values of carotid intima-media thickness and coronary flow reserve in cardiovascular mortality of peritoneal dialysis patients.
详细描述
Endothelial dysfunction (ED) is a precursor and cause of cardiovascular diseases. Defining of endothelial thickness and coronary microvascular function could be useful for detecting ED. Endothelial dysfunction could be assessed by coronary flow reserve (CFR), carotid intima media thickness (IMT). Repeating measurement of IMT and CFR could be predictor of cardiovascular events and mortality in peritoneal dialysis patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Peritoneal dialysis patients whose followed up at least six months from October 1994 to October 2011 (for study group)
- •Kidney transplant recipients whose followed up at least six months from October 1994 to October 2011 (for control group)
排除标准
- •diabetes mellitus
- •valvular heart disease,
- •any prior coronary intervention and congestive heart failure
- •Patients whose left anterior descending coronary artery (LAD) could not be visualized adequately by Doppler echocardiography were also excluded.
结局指标
主要结局
Diseases morbidity
时间窗: 10-15 years
次要结局
- Patient Survival(10-15 years)
研究者
Yasar Caliskan
MD Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine
Istanbul University