Comparison Of a sedative drug with a combination with opioid for awake intubation in Patients with difficult airway.
Not Applicable
Completed
- Conditions
- Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx
- Registration Number
- CTRI/2021/03/031760
- Lead Sponsor
- IMS and SUM Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. ASA grade I and II
2. Patients with difficult intubation
Exclusion Criteria
1. Refusal of patient to participate in the study
2. ASA grade II/ III
3. Any allergy to dexmedetomidine
4. Patients on any of the following:
a. Higher degree of A-V block
b. Treatment with ACE Inhibitors, digoxin or beta adrenergic antagonist
c. Treatment with alpha-2 agonist
d. Long term use of benzodiazepine or TCA
e. Treat with anticoagulants
5. Bleeding disorders
6. Pregnant and nursing women
7. Morbid obesity
8. Lack of cooperative and effective communication
9. Patients requiring post operative ventilatory support
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Airway obstruction score was evaluated using a 3 degree scale <br/ ><br>2. Intubation score was evaluated according to Vocal cord movement <br/ ><br>3. Coughing <br/ ><br>4. Limb movement <br/ ><br>5. Fiberoptic intubation comfort score indicating patient tolerance; It was evaluated using a 5 point score <br/ ><br>6. Ramsay sedation score: using 6 points <br/ ><br>7. Patient satisfaction score <br/ ><br>Timepoint: At the time of attempting awake fibre optic intubation
- Secondary Outcome Measures
Name Time Method 1. Haemodynamic variables: <br/ ><br>a. heart rate <br/ ><br>b. systolic blood pressure <br/ ><br>c. diastolic blood pressure <br/ ><br>2. Any episode of oxygen desaturation ( less than 90%) or bradycardia (HR less than 60 beats/minute).Timepoint: Haemodynamic variables: <br/ ><br>1. Baseline: Before drug administration. <br/ ><br>2. With the start of the airway manipulation technique (20 min after drug administration). <br/ ><br>3. Immediately after intubation. <br/ ><br>