NCT03887741已完成1 期
Plasmapheresis Versus Plasma Infusion from Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease Progression: an Unblinded Phase 1 Safety, Methodological and Exploratory Biomarkers Study.
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Adverse events
研究概览
简要总结
Determine safety of plasma infusion or exchange in APOE 44 patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Plasmapheresis
Experimental
3 patients will have monthly plasmapheresis for 6 months and followed for a total of 12 months
干预措施: Plasmapheresis (Biological)
Plasma infusion
Experimental
3 patients will have biweekly plasma infusion for 6 months and followed for 12 months
干预措施: Plasma infusion (Biological)
结局指标
主要结局
Adverse events
时间窗: One year
Number of adverse events reported
次要结局
未报告次要终点
研究者
Neill R. Graff-Radford, M.D.
Principal Investigator
Mayo Clinic
研究点 (1)
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