Dysfunctional voiding: exploring disease transition from childhood to adulthood

Conditions: Dysfunctional voiding (DV) is a condition characterized by an impaired relaxation of the pelvic floor musculature during voiding, with a poorly understood etiology. In children and adults it is known to cause residual urine after voiding with subsequent UTI’s, and daytime urinary incontinence (DUI) due to an impaired sensation for the filling state of the bladder.

Registration Number: NL-OMON21136

Lead Sponsor: MC

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 130

Inclusion Criteria

In order to be eligible to participate in the study, a subject must meet all of the following criteria:

1.Female gender
2.Diagnosed with DV in childhood, defined according to the ICCS standardisation paper (3).
3.Completed follow-up (assessment of relief from infections and incontinence at 12 months after initial randomization) in the RCT of Klijn et al .
Klijn AJ, Uiterwaal CSPM, Vijverberg MAW, Winkler PLH, Dik P, de Jong TPVM. Home Uroflowmetry Biofeedback in Behavioral Training for Dysfunctional Voiding in School-Age Children: A Randomized Controlled Study. J Urol. 2006;175(6):2263–8.

Exclusion Criteria

1.Neurological bladder disorders

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Persisting or relapse of DV from baseline and/or after conservative treatment to adulthood, expressed as the percentage of adults with DV. DV is herein determined according to ICS criteria as the presence of a staccato and/or intermittent urinary flow

Secondary Outcome Measures

Name	Time	Method
-Daytime urinary incontinence in days per week, defined as any form of involuntary leakage of urine.<br>-Post-void residual defined as the volume of urine in milliliter left in the bladder at the end of micturition.<br>-Urinary tract infections , defined as a bacteriuria, with or without fever, with need for antibiotic treatment in the last six months.<br>-Conservative treatment success, as described in the study of Klijn et al. (previous mentioned) and quantified according to the ICCS criteria.<br>