Damaged gut due to dirty and unclean surroundings and its effects on absorption of proteins in food consumed by childre
Not Applicable
- Registration Number
- CTRI/2017/02/007921
- Lead Sponsor
- Bill and Melinda Gates Foundation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Controls and cases will be of both genders, aged 18 - 24 months, all consuming an adequate daily intake of energy and protein and not being breast-fed.
2.Controls will have good health, normal weight and height and normal gut function.
3.Cases will be otherwise healthy except for presence of EED and possibly stunting (HAZ < -2SD).
Exclusion Criteria
1.For all children will be presence of chronic infection(s) or a pre-existing medical condition
2.Recent history ( <1 month) of intestinal or other morbidity
3.Antibiotic usage in the last 4 weeks of study recruitment.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tryptophan Flux, oxidation, and bioavailability for body protein synthesis, and niacin synthesis, Enrichment of Trp in VLDL-apoB-100, Concentrations of Amino Acids, Trp, Kynurenine ( K:T ratio), Albumin, Prealbumin, Fibrinogen, CRP and niacin concentrations, IGF-1, Inflammatory cytokines INF-α, TNF-α, markers of gut function,fecal neopterin, myeloperoxidase, alpha-1 anti-trypsin, Reg1B and plasma EndoCAb, Total and Resting Energy Expenditures, body composition <br/ ><br>Timepoint: One time point
- Secondary Outcome Measures
Name Time Method Determining rice, finger millet and whole egg digestibility using the same method proposed for mung bean <br/ ><br>Timepoint: One time point;Markers of gut function: fecal neopterin, myeloperoxidase, alpha-1 anti-trypsin, Reg1B and plasma EndoCAb, fecal microbial analysis <br/ ><br>Total Energy Expenditure (TEE) and body composition in the study participantsTimepoint: One time point