NL-OMON37267已完成不适用
Antiretroviral therapy and peripheral T cell apoptosis - ARTA
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- subjects must be willing and able to provide written informed consent
- •- Age >18 and <65 years
- •- Body weight >40 and <125kg
- •- Infected with HIV-1
- •- Effective HAART >1 year
- •- subjects must meet the following criteria per patient group:
- •o *PI-group* (n=15): HAART must consist of a protease inhibitor (e.g. atazanavir, lopinavir, darunavir), boosted with ritonavir, in combination with backbone therapy consisting of tenefovir and emtricitabine but without any other antiretroviral medicine.
- •o *NNRTI-group* (n=15): HAART must consist of a non-nucleoside reverse transcriptase inhibitor (efavirenz, nevirapine) in combination with backbone therapy consisting of tenofovir and emtricitabine without any other antiretroviral medicine.
排除标准
- •- Detectable HIV-RNA within 6 months before inclusion
- •- CD4-count <350
- •- Switch of HAART within 6 months before inclusion
- •- Any known pre-existing condition likely to interfere with T cell apoptosis:
- •o Systemic infections (other than HIV)
- •o Systemic auto-immune disease
- •o Systemic immunomodulatory treatment
- •o Haematologic disease
- •o Pregnancy
- •o Immunodeficiency
- •- Subjects who are closely related to the investigators of the study
研究者
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