Efficacy of Dexamethasone in reducing pain, nausea and vomiting, improve mobilisation and reduce hospital stay in hip and knee arthroplasty: a double blind controlled trial

Phase 4

Completed

• Conditions: Hip Arthritis; Knee Arthritis; Musculoskeletal - Osteoarthritis; Surgery - Surgical techniques

• Registration Number: ACTRN12615000540516
• Lead Sponsor: Jonathan Mulford

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-05-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 142

Inclusion Criteria

People who are presenting to preadmission clinic for single joint hip or knee arthroplasty.
-Able to provide informed consent
-Age 18 years and older

Exclusion Criteria

-Type 1 or type 2 diabetes mellitus; renal failure; hepatic failure
-Use of oral corticosteroids over past 6 months
-Allergic or adverse reaction to corticosteroids in the past
-Allergy to the food preservative Sulfite (this does not include Sulpha containing medications)
-Active peptic ulcer disease with symptoms present in the previous 6 months
-Previous GIT haemorrhage
-Pregnancy and lactation
-Past history of psychotic illness (including psychotic depression)
-Current systemic fungal infection
-Administration of live vaccine in the previous 3 months
-Myasthenia gravis

Study & Design

• Study Type: Interventional
• Study Design: Not specified