Repeat vs single shot antibiotic prophylaxis in major abdominal surgery – prospective observational study

Conditions: C18
C22.0
Malignant neoplasm of colon
Liver cell carcinoma

Registration Number: DRKS00027892

Lead Sponsor: niversitätsklinik Heidelberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 300

Inclusion Criteria

Patients 18 years old or older
Planned elective major abdominal surgery
Absence of acute or chronic infection
Ability of subject to understand character and individual consequences of the clinical study
Written informed consent

Exclusion Criteria

Patients younger than 18 years of age
Absence of an informed consent form
Current antibiotic treatment

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br>Surgical site infections (within 30 days after surgery, according to the CDC criteria) <br><br>

Secondary Outcome Measures

Name	Time	Method
Sepsis within 30 days after surgery<br>Severe Sepsis within 30 days after surgery<br>Frequency of repeated perioperative antibiotic prophylaxis<br>Time between first and second perioperative dose<br>Blood transfusions during the hospital stay<br>Perioperative volume management<br>Antibiotic serum concentration prior to redosing<br>Antibiotic serum concentration prior to closure of the abdomen<br>Other postoperative infections within 30 days after surgery<br>Occurrence of resistant bacteria during postoperative hospital stay<br>Postoperative antibiotic treatment for any condition within 30 days after surgery<br>Blood parameters of inflammation during postoperative hospital stay<br>Length of hospital stay after surgery<br>Re-admission due to infectious complications within 30 days after surgery<br>Total antibiotic cost within 30 days after surgery<br>Total treatment cost within postoperative hospital stay<br>