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临床试验/CTRI/2022/09/045883
CTRI/2022/09/045883已完成不适用

Early diagnosis of ICU acquired weakness in mechanically ventilated patients in intensive care unit

Manipal College of Health Professions1 个研究点 分布在 1 个国家目标入组 385 人开始时间: 2022年9月30日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
385
试验地点
1
主要终点
Percantage of people diagnosed with ICU acquired weakness based on MRC sum score

研究概览

简要总结

ICU acquired weakness is commonly seen in patients who are admitted to the ICU. It is associated with prolonged ICU stay or patients on mechanical ventilation for a longer duration. This lead to poor progression of the patient. A routine assessment for muscle strength is not done in an intensive care unit. Hence the early diagnosis of ICU acquired weakness is often missed and the chances of complications increase. Assessing muscle strength in a regular routine may help to determine the plan of treatment at the beginning if muscle weakness is acquired. This may help to guide further interventions for ICU acquired weakness. Patients will be screened according to the selection criteria. MRC sum score will be performed on these patients. There are six group of muscles that will be tested on both sides. Score will be given from one to five depending upon the grading of the scale. A score less than forty eight will be considered to be cut off for ICU acquired weakness. Muscle strength assessment will be carried out daily till the patient develops weakness or is discharged or is discharged against medical advice. The score will be noted in the data collection sheet. Data will be analyzed at the end of the study period.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • Patients on mechanical ventilation in ICU for more than 48 hours APACHE II score more than 12.

排除标准

  • Diagnosed with pre existing neuromuscular disease Pregnancy Pre existing systemic vascular involvement such as systemic lupus erythematous Patients on inotropes.
  • Dosage more than 5ml per hour Platelet count below 50,000 per microlitre.

结局指标

主要结局

Percantage of people diagnosed with ICU acquired weakness based on MRC sum score

时间窗: First recording when the participant obeys 5 standardized questions which is followed by every day till the patient develops weakness or is discharged or discharged against medical advice or stops following commands or death

Report at what day the patient developes weakness

时间窗: First recording when the participant obeys 5 standardized questions which is followed by every day till the patient develops weakness or is discharged or discharged against medical advice or stops following commands or death

次要结局

  • Number of days on mechanical ventilator, ICU stay(When one of these events occur the patient develops weakness or is discharged or discharged against medical advice or stops following commands or death)

研究者

发起方
Manipal College of Health Professions
申办方类型
Research institution

研究点 (1)

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