Effects of Low-intensity Resistance Exercise Training and Diet on Central Hemodynamics and Arterial Stiffness in Obese Middle-aged Women With High Blood Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Blood pressure
研究概览
简要总结
- Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in large artery (aorta) stiffness. However, along with decreases in fat mass, hypocaloric diet reduces muscle mass. Low-intensity resistance exercise training (LIRET) results in similar increases in muscle mass and strength than those observed after high-intensity resistance exercise.
- The investigators hypothesis is that weight loss via diet combined with LIRET would additively reduce arterial stiffness and blood pressure (BP) in obese women. The investigators also hypothesize that the improved arterial function with weight loss would be associated with beneficial changes in the main mechanisms involved in BP regulation.
详细描述
The purpose of the study is to examine the effects of 12 weeks of low-intensity resistance exercise training (LIRET) and diet on arterial function, autonomic function, and body composition in obese women with high blood pressure (BP). Specific aims of the study are to:
- To evaluate the extent to which diet and LIRET will improve body composition assessed by changes in fat mass and lean mass using dual-energy x-ray absorptiometry and waist circumference.
- To investigate that combined diet and LIRET are more efficacious than either treatment alone in ameliorating cardiovascular disease risk factors by assessing arterial stiffness (aortic, systemic, and leg), aortic BP and wave reflection, and autonomic function (heart rate variability, vascular sympathetic activity [low-frequency power of systolic BP variability], and baroreflex sensitivity). Circulating levels of adipocytokines (adiponectin and leptin) and endothelial-derived vasodilators (NO metabolites [NOx] and prostacyclin) and vasoconstrictors (endothelin-1 and prostaglandin F2α) will be assessed as secondary outcome variables.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •40 to 65 years of age
- •Body mass index of 27-39.9
- •Sedentary or low active (less than 2 hr per wk)
排除标准
- •Younger than 40 or older than 65 years of age
- •Body mass index lower than 27, or 40 or higher
- •Physically active or competitively active
- •Systolic blood pressure higher than 140 mmHg
- •Use of hormone replacement therapy of less than 1 yr
- •Use of calcium channel blocker or beta blockers
- •Type 1 diabetes
- •Uncontrolled type 2 diabetes
研究组 & 干预措施
Resistance exercise training
Lower-body exercises 3 times per wk for 12 wk
干预措施: Resistance exercise training (Other)
Hypocaloric diet
This arm involves 12 wk of the standard Nutrisystem foods plan complemented by fresh produce and dairy. Subjects consume breakfast, lunch, dinner, and one (women) or two (men) snacks per day.
干预措施: Hypocaloric diet (Other)
Resistance exercise training & diet
Lower-body exercise training and diet
干预措施: Resistance exercise training & diet (Other)
Control
This arm involves not making any change to the subject's lifestyle at the moment of the start of the intervention and for 12 wk.
结局指标
主要结局
Blood pressure
时间窗: 12 weeks
Non-invasive measures of brachial and aortic blood pressure
次要结局
- Autonomic Function(12 weeks)
- Arterial Stiffness(12 weeks)
- Endothelial Function(12 weeks)
- Body Composition(12 weeks)
- Pressure Wave Reflection(12 weeks)
研究者
Arturo Figueroa
Associate Professor
Florida State University