Serum allergens and innate lymphoid cells in eosinophilic esophagitis.

Completed

• Conditions: (idiopathic) eosinophilic esophagitis; Allergic esophagitis; 10017969; 10001708

• Registration Number: NL-OMON35461
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

* Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid-esophageal biopsies
* Written informed consent
* Age 18 * 75 years

Exclusion Criteria

* History of peptic ulcer disease
* History of Barrett*s esophagus
* History of GI cancer
* History of GI tract surgery (except appendectomy)
* ASA class IV or V

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- IgE reactivity to recombinant allergens of common foods and inhalants in<br /><br>adult EoE patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The number of ILC2 cells in periferal blood of adult EoE patients.<br /><br>- Biomarkers for disease activity of eosinophilic esophagitis before and after<br /><br>8 weeks of standard PPI treatment.</p><br>